WAO consensus on DEfinition of Food Allergy SEverity (DEFASE).
WAO consensus on DEfinition of Food Allergy SEverity (DEFASE).
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DOI：
10.1016/j.waojou.2023.100753
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发表时间：
2023-03
影响因子：
5.1
通讯作者：
Fiocchi, Alessandro
中科院分区：
文献类型：
--
作者：
Arasi, Stefania;Nurmatov, Ulugbek;Dunn-Galvin, Audrey;Roberts, Graham;Turner, Paul J.;Shinder, Sayantani B.;Gupta, Ruchi;Eigenmann, Philippe;Nowak-Wegrzyn, Anna;Ansotegui, Ignacio J.;Fernandez Rivas, Montserrat;Petrou, Stavros;Tanno, Luciana K.;Vazquez-Ortiz, Marta;Vickery, Brian;Wong, Gary;Alvaro-Lozano, Montserrat;Asaria, Miqdad;Begin, Philippe;Bozzola, Martin;Boyle, Robert;Brough, Helen;Cardona, Victoria;Chinthrajah, R. Sharon;Cianferoni, Antonella;Deschildre, Antoine;Fleischer, David;Gazzani, Flavio;Gerdts, Jennifer;Giannetti, Marilena;Greenhawt, Matthew;Antonieta Guzman, Maria;Hossny, Elham;Kauppi, Paula;Jones, Carla;Lucidi, Francesco;Ortega, Olga Patricia Monge;Munblit, Daniel;Muraro, Antonella;Pajno, Giovanni;Podesta, Marcia;del Rio, Pablo Rodriguez;Said, Maria;Santos, Alexandra;Shaker, Marcus;Szajewska, Hania;Venter, Carina;Warren, Cristopher;Winders, Tonya;Ebisawa, Motohiro;Fiocchi, Alessandro
虽然已经开发了几种速发过敏反应严重程度的评分系统，但对食物过敏疾病的定义和分类缺乏共识。制定关于食物过敏严重程度的国际共识（DEFASE）评分系统，在全球范围内使用。我们对11个数据库进行了混合方法系统综述（SR），以获取有关食物过敏管理严重程度的已发表和未发表文献，并成立了一个国际专家小组。基于我们在第1阶段的发现，我们起草了两轮改良电子德尔菲（e-德尔菲）调查的声明。确定了一个有目的地选择的多学科食物过敏国际专家小组（n = 60），并发送了一份结构化问卷，包括一组关于与症状相关的食物过敏严重程度、健康相关生活质量和经济影响的不同领域的陈述。参与者被要求在5分制的李克特量表上对他们对每个陈述的同意程度进行评分，从“强烈同意”到“强烈不同意”。计算中位评分和一致率。共识被先验地定义为，如果70%或更多的小组成员在第二轮之后将一项声明评为“强烈同意”或“同意”，则达成共识。根据反馈意见，又进行了两轮在线投票。我们在第一轮和第二轮分别收到了92%和85%的德尔菲小组成员的回复。在总体评分和作为DEFASE评分基本组成部分的所有5个特定关键领域达成共识。DEFASE评分是第一个综合的食物过敏严重程度分级，不仅考虑单一反应的严重程度，而且考虑整个疾病谱。关于食物过敏疾病的评分系统，国际上已达成共识。它提供了一个评估网格，这可能有助于评估食物过敏的严重程度。第三阶段将涉及在研究环境中验证评分系统，并在临床实践中实施。
While several scoring systems for the severity of anaphylactic reactions have been developed, there is a lack of consensus on definition and categorisation of severity of food allergy disease as a whole. To develop an international consensus on the severity of food allergy (DEfinition of Food Allergy Severity, DEFASE) scoring system, to be used globally. We conducted a mixed-method systematic review (SR) of 11 databases for published and unpublished literature on severity of food allergy management and set up a panel of international experts. Based on our findings in Phase 1, we drafted statements for a two-round modified electronic Delphi (e-Delphi) survey. A purposefully selected multidisciplinary international expert panel on food allergy (n = 60) was identified and sent a structured questionnaire, including a set of statements on different domains of food allergy severity related to symptoms, health-related quality of life, and economic impact. Participants were asked to score their agreement on each statement on a 5-point Likert scale ranging from “strongly agree” to “strongly disagree”. Median scores and percentage agreements were calculated. Consensus was defined a priori as being achieved if 70% or more of panel members rated a statement as “strongly agree” to “agree” after the second round. Based on feedback, 2 additional online voting rounds were conducted. We received responses from 92% of Delphi panel members in round 1 and 85% in round 2. Consensus was achieved on the overall score and in all of the 5 specific key domains as essential components of the DEFASE score. The DEFASE score is the first comprehensive grading of food allergy severity that considers not only the severity of a single reaction, but the whole disease spectrum. An international consensus has been achieved regarding a scoring system for food allergy disease. It offers an evaluation grid, which may help to rate the severity of food allergy. Phase 3 will involve validating the scoring system in research settings, and implementing it in clinical practice.
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3.7
作者：
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