The Jidong Eye Cohort Study: objectives, design, and baseline characteristics.
The Jidong Eye Cohort Study: objectives, design, and baseline characteristics.
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冀东眼科队列研究：目标、设计和基线特征
DOI：
10.1186/s40662-020-00223-1
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发表时间：
2020-12-29
期刊：
影响因子：
--
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Yang K;Cui L;Zhang G;Wang X;Zhu X;Xiao Y;Su B;Song D;Zhang X;Zheng Y;Lu F;Qu J;Li M
To describe the objective, design and baseline characteristics of the Jidong Eye Cohort Study (JECS), a community-based cohort in China based on etiology, imaging and biomarkers. The JECS will clarify the pathogenesis of visual impairment and status of ocular indicators in the occurrence and progression of cardio-cerebrovascular and neurological diseases. Between August 2019 and January 2020, the JECS recruited consecutive participants aged 18 years and older from the Jidong communities in China. The demographic and clinical characteristics were collected by trained site personnel via face-to-face interviews. The relevant biological samples were also collected. The participants underwent comprehensive ophthalmic examination, such as retinal photography and optical coherence tomography (OCT) angiography. The following outcomes were measured annually: ocular vascular abnormality, optic nerve degeneration, cardiovascular diseases (CVD) and neurological diseases. The study will be performed until 2024. Among 3377 participants, the average age was 45.0 ± 12.5 years and 1809 (53.6%) were women. Hypertension occurred in 825 individuals (25.0%), diabetes in 258 (7.7%), hyperglycemia in 474 (14.2%), and a CVD history in 100 (3.0%). The mean best-corrected visual acuity was 0.1 logMAR in the recruited subjects. The average OCT signal index was 8.2 ± 1.2. Additionally, the mean vessel densities for the entire measured area were 46.4% and 50.8% for the superficial and deep vascular complex, respectively. Mean area and perimeter of foveal avascular zone was 0.3 mm2 and 2.3 mm. The JECS is a large community-based prospective cohort in North China. Rich data collected from this study will provide the opportunity to identify risk factors, imaging, and biomarkers of visual impairment (either ocular vascular anomalies or optic nerve degeneration) and to evaluate their associations with CVD and neurological diseases.
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影响因子：
37.8
作者：
Muntner P;Carey RM;Gidding S;Jones DW;Taler SJ;Wright JT Jr;Whelton PK
通讯作者：
Whelton PK
影响因子：
13.7
作者：
Colijn JM;Buitendijk GHS;Prokofyeva E;Alves D;Cachulo ML;Khawaja AP;Cougnard-Gregoire A;Merle BMJ;Korb C;Erke MG;Bron A;Anastasopoulos E;Meester-Smoor MA;Segato T;Piermarocchi S;de Jong PTVM;Vingerling JR;Topouzis F;Creuzot-Garcher C;Bertelsen G;Pfeiffer N;Fletcher AE;Foster PJ;Silva R;Korobelnik JF;Delcourt C;Klaver CCW;EYE-RISK consortium;European Eye Epidemiology (E3) consortium
通讯作者：
European Eye Epidemiology (E3) consortium
影响因子：
8.3
作者：
Mitchell, P;Wang, JJ;Smith, W
通讯作者：
Smith, W
影响因子：
4
作者：
Meng, Qianli;Cui, Ying;Guo, Haike
通讯作者：
Guo, Haike
影响因子：
8.2
作者：
Ostergaard, Leif;Finnerup, Nanna B.;Terkelsen, Astrid J.;Olesen, Rasmus A.;Drasbek, Kim R.;Knudsen, Lone;Jespersen, Sune N.;Frystyk, Jan;Charles, Morten;Thomsen, Reimar W.;Christiansen, Jens S.;Beck-Nielsen, Henning;Jensen, Troels S.;Andersen, Henning
通讯作者：
Andersen, Henning