Neuroplasticity and the Biological Role of Brain Derived Neurotrophic Factor in the Pathophysiology and Management of Depression.
Neuroplasticity and the Biological Role of Brain Derived Neurotrophic Factor in the Pathophysiology and Management of Depression.
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神经可塑性和脑源性神经营养因子在抑郁症的病理生理学和治疗中的生物学作用。
DOI：
10.7759/cureus.11396
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发表时间：
2020-11-09
期刊：
影响因子：
--
通讯作者：
Mostafa JA
中科院分区：
文献类型：
--
作者：
Chakrapani S;Eskander N;De Los Santos LA;Omisore BA;Mostafa JA
抑郁症是一种精神疾病，如果不加以治疗，可能会产生严重的影响。研究涉及神经营养因子称为脑源性神经营养因子（BDNF）脑源性神经营养因子（BDNF）及其相关信号通路的研究，巩固了我们对抑郁症病理生理的认识。本文综述的目的是更好地了解BDNF水平降低与抑郁症的关系，以及抗抑郁药如何通过增加BDNF水平来促进抑郁症的治疗。具体方法是了解BDNF及其受体TrkB的关键参与（原肌球蛋白受体激酶B）以及它们的相互作用和随后的细胞内信号级联如何带来增强的神经可塑性变化。在这篇文献综述中，我们检索了过去关于BDNF的综述文章。我们使用PubMed收集数据，并对我们的发现进行了总结。结果表明，压力和抑郁通过降低BDNF水平有助于神经可塑性的变化，而抗抑郁药通过增强BDNF水平能够产生积极的神经可塑性结果，从而有助于解决抑郁症状。在这篇论文中，我们将深入研究如何更好地了解涉及BDNF的神经回路将使我们能够了解目前的抗抑郁药如何在大脑边缘区域工作，以及寻找新的快速-在临床实践中使用的抗抑郁药。
Depression is a mental illness that can have serious implications if left untreated. Studies involving a neurotrophic factor called brain derived neurotrophic factor (BDNF) and its associated signaling pathways have solidified our understanding of the pathophysiology of depression. The objective of this literature review is to gain a better understanding of the mechanism by which reduced levels of BDNF are implicated in depression and how antidepressants facilitate the treatment of depression by increasing BDNF levels. The specific approach is to learn about the key involvements of BDNF and its receptor TrkB (tropomyosin receptor kinase B) and how their interactions and subsequent intracellular signaling cascades bring about enhanced neuroplastic changes. In this literature review, we searched for past review articles focusing on BDNF. We collected data using PubMed and created a summary of our findings. The results showed that stress and depression through the reduction of BDNF levels contribute to neuroplastic changes while antidepressants through enhanced BDNF levels are able to generate positive neuroplastic outcomes and thereby help resolve depressive symptoms. In this paper, we will delve into how a better understanding of the neural circuitry involving BDNF will enable us to both understand how current antidepressants work in the limbic regions of the brain as well as search for novel rapid-acting antidepressants to use in clinical practice.
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影响因子：
16.2
作者：
Kessels, Helmut W.;Malinow, Roberto
通讯作者：
Malinow, Roberto
影响因子：
82.9
作者：
Kang, Hyo Jung;Voleti, Bhavya;Hajszan, Tibor;Rajkowska, Grazyna;Stockmeier, Craig A.;Licznerski, Pawel;Lepack, Ashley;Majik, Mahesh S.;Jeong, Lak Shin;Banasr, Mounira;Son, Hyeon;Duman, Ronald S.
通讯作者：
Duman, Ronald S.
影响因子：
7.6
作者：
Boldrini, Maura;Santiago, Adrienne N.;Mann, J. John
通讯作者：
Mann, J. John
影响因子：
3.1
作者：
Drevets, Wayne C.;Price, Joseph L.;Furey, Maura L.
通讯作者：
Furey, Maura L.
抗抑郁药会增加人海马中的神经祖细胞。
影响因子：
7.6
作者：
Boldrini, Maura;Underwood, Mark D.;Hen, Rene;Rosoklija, Gorazd B.;Dwork, Andrew J.;Mann, J. John;Arango, Victoria
通讯作者：
Arango, Victoria