On the inverse problem in optical coherence tomography.

On the inverse problem in optical coherence tomography.
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光学相干层析成像中的逆问题。

DOI:
10.1038/s41598-023-28366-w
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发表时间:
2023-01-27
期刊:
影响因子:
4.6
通讯作者:
--
中科院分区:
综合性期刊3区
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--
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在光学相干层析成像的背景下,我们研究了恢复样品折射率信息的逆问题。使用两种不同的方法,我们讨论了反问题的局限性,这导致它是不适定的,主要是由于反射几何中可用视角有限的结果。首次从弱散射近似下的衍射层析成像的理论角度考虑了这一点。然后,我们用变分方法研究了整个非线性反问题。这提供了解的非唯一性的另一个例证,并表明即使是非线性(强散射)场景也遭受与线性问题类似的命运,样本的可观测空间傅立叶分量占据有限的支持。通过算例,我们展示了变分方法和绕射层析方法对反问题解的比较。
We examine the inverse problem of retrieving sample refractive index information in the context of optical coherence tomography. Using two separate approaches, we discuss the limitations of the inverse problem which lead to it being ill-posed, primarily as a consequence of the limited viewing angles available in the reflection geometry. This is first considered from the theoretical point of view of diffraction tomography under a weak scattering approximation. We then investigate the full non-linear inverse problem using a variational approach. This presents another illustration of the non-uniqueness of the solution, and shows that even the non-linear (strongly scattering) scenario suffers a similar fate as the linear problem, with the observable spatial Fourier components of the sample occupying a limited support. Through examples we demonstrate how the solutions to the inverse problem compare when using the variational and diffraction-tomography approaches.
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