A tumor-microenvironment-responsive nanomaterial for cancer chemo-photothermal therapy.
A tumor-microenvironment-responsive nanomaterial for cancer chemo-photothermal therapy.
复制标题
用于癌症化学光热治疗的肿瘤微环境响应性纳米材料
作者：
Taxol (TAX) is a typical anticancer drug that is widely used in clinical treatment of cancer, while gold nanorods (AuNRs) are a kind of well-known material applied for photothermal therapy (PTT). The therapeutic outcome of TAX in chemotherapy is however limited by drug resistance, while AuNRs often show poor accuracy in PTT. To optimize the functions of TAX and AuNRs, we developed a hydrogen peroxide (H2O2)-triggered nanomaterial (LV–TAX/Au@Ag) for combined chemo-photothermal therapy. In normal tissues, TAX is protected in the lipid bilayer and isolated from the surrounding normal cells, while AuNRs are coated with silver shells and show low photothermal capacity. However, after reaching the tumor tissues, the silver shells can be etched by endogenous H2O2 in the tumor microenvironment, and the photothermal properties of AuNRs are then recovered. Meanwhile, the generated oxygen destabilizes the LV, which makes the 100 nm sized nanosystems disassemble into the smaller sized TAX and AuNRs, leading to the deep penetration and direct interaction with tumor tissues. The related in vitro experiments proved the validity of this “turn off/on” effect. Extensive necrosis and apoptosis were observed in the tumor tissues and the proliferation of solid tumor was greatly suppressed due to this combined chemo-photothermal therapy. In addition, no significant damage was found in normal tissues after the treatment of LV–TAX/Au@Ag. Therefore, the strategy to achieve environmental response by modifying the photothermal agents enhanced the efficiency and safety of nanomedicine, which may help improve cancer treatment.
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影响因子：
17.1
作者：
Jang, Boseung;Park, Jin-Young;Choi, Yongdoo
通讯作者：
Choi, Yongdoo
影响因子：
16.6
作者：
Park, Chiyoung;Lee, Kyuho;Kim, Chulhee
通讯作者：
Kim, Chulhee
影响因子：
120.7
作者：
Jemal, A;Ward, E;Thun, M
通讯作者：
Thun, M
近红外响应 Aurod@pNIPAAm-PEGMA 纳米凝胶作为光动力治疗药物递送载体的合成和表征
影响因子：
--
作者：
Shang T;Wang CD;Ren L;Tian XH;Li DH;Ke XB;Chen M;Yang AQ
通讯作者：
Yang AQ
影响因子：
4.6
作者：
Darwish, Wael M.;Bayoumi, Noha A.;El-Kolaly, Mohamed T.
通讯作者：
El-Kolaly, Mohamed T.