The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders.
The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders.
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DOI：
10.9758/cpn.2018.16.4.383
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发表时间：
2018-11-30
期刊：
影响因子：
--
通讯作者：
Fındıklı E
中科院分区：
文献类型：
--
作者：
Altun H;Kurutaş EB;Şahin N;Güngör O;Fındıklı E
自闭症谱系障碍（ASD）是一种复杂的神经发育综合征，其病因日益普遍，但尚未完全了解。人们认为维生素D、复合B族维生素水平和同型半胱氨酸与环境因素有关，在ASD中很重要。本研究旨在检测ASD患者血清维生素D、维生素D受体（VDR）、同型半胱氨酸、维生素B6、维生素B12和叶酸水平。在这项研究中，血清维生素D和VDR，同型半胱氨酸，维生素B6，B12和叶酸水平测定60例ASD患者（年龄3至12岁）和45名年龄性别匹配的健康对照。此外，钙，磷和碱性磷酸酶，这是与维生素D代谢，从两组的血清进行了测量。采用儿童孤独症评定量表（汽车）评估ASD严重程度。ASD患者血清维生素D和VDR水平明显低于对照组。然而，ASD患者的同型半胱氨酸水平显著升高，维生素B6、维生素B12和叶酸水平也降低。总汽车评分与同型半胱氨酸呈正相关，与维生素D、B6、B12、叶酸和VDR呈负相关。这项综合性研究检查了许多参数，表明血清中维生素D，B6，B12，叶酸和VDR的低水平以及高同型半胱氨酸在ASD的发病机制中很重要。然而，需要进一步的研究来确定这些参数的确切机制及其对ASD病因学和治疗的贡献。
Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome with an increasingly prevalent etiology, yet not fully understood. It has been thought that vitamin D, complex B vitamin levels and homocysteine are associated with environmental factors and are important in ASD. The aim of this study was to examine serum vitamin D, vitamin D receptor (VDR), homocysteine, vitamin B6, vitamin B12 and folate levels in ASD. In this study, serum vitamin D and VDR, homocysteine, vitamins B6, B12 and folate levels were determined in 60 patients with ASD (aged 3 to 12 years) and in 45 age-gender matched healthy controls. In addition, calcium, phosphorus and alkaline phosphatase, which are associated with vitamin D metabolism, were measured from serum in both groups. ASD severity was evaluted by the Childhood Autism Rating Scale (CARS). Serum vitamin D and VDR were substantially reduced in patients with ASD in comparision to control group. However, homocysteine level was significantly higher and vitamin B6, vitamin B12 and folate were also reduced in patients with ASD. Total CARS score showed a positive association with homocysteine and a negative correlation with vitamins D, B6, B12, folate and VDR. This comprehensive study, which examines many parameters has shown that low serum levels of vitamins D, B6, B12, folate and VDR as well as high homocysteine are important in the etiopathogenesis of ASD. However, further studies are required to define the precise mechanism(s) of these parameters and their contributions to the etiology and treatment of ASD.
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