bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy.
bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy.
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bcl-2 蛋白表达与放疗治疗的早期头颈癌的复发和生存相关。
作者：
O. Gallo;V. Boddi;A. Calzolari;Laura Simonetti;M. Trovati;S. Bianchi
固有的细胞放射抗性在放射治疗（RT）失败中起着至关重要的作用。原癌基因 bcl-2 编码一种抑制细胞凋亡的蛋白质，细胞凋亡是由几种基因毒剂（包括伽马辐射）诱导的细胞死亡的常见机制。因此，bcl-2 基因表达可能参与人类肿瘤放射抗性的复杂机制，并具有一些预后意义。在这项研究中，我们分析了 bcl-2 表达对初次接受放疗的早期头颈鳞状细胞癌 (SCCHN) 患者 5 年无病生存率和总生存率的预测相关性。通过免疫组织化学对 71 名接受治疗性 RT 治疗的连续 I-II 期 SCCHN 患者的石蜡包埋切片上的 bcl-2 表达进行分析。我们在所研究的 21% 的 SCCHN 中检测到了 bcl-2 蛋白。观察到烟草暴露与 bcl-2 蛋白表达之间存在提示性关联（P < 0.1）；这种关联在初次放疗失败的患者中更为明显 (P = 0.03)。此外，我们记录了复发患者的放射后活检中 bcl-2 免疫反应性肿瘤的发生率高于放射前的患者 (P = 0.03)。在单变量和多变量分析中，bcl-2 表达是 RT 5 年内无病生存（分别为 P = 0.08 和 P = 0.01）和总生存（P = 0.004 和 P = 0.05）的最重要指标。本研究表明，原癌基因 bcl-2 在一些 SCCHN 中异常表达，其表达可能被证明是选择常规放疗患者的有用工具，具有明确的预后意义。
Inherent cellular radioresistance plays a critical role in the failure of radiation therapy (RT). The proto-oncogene bcl-2 encodes a protein that inhibits apoptosis, a common mechanism of cell death induced by several genotoxic agents, including gamma-radiation. Thus, it is likely that bcl-2 gene expression could be involved in the complex mechanisms of radioresistance in human tumors with some prognostic implications. In this study, we analyzed the predictive relevance of bcl-2 expression on 5-year disease-free and overall survival in patients with early stage squamous cell carcinoma of the head and neck (SCCHN) primary treated with RT. The expression of bcl-2 was analyzed by immunohistochemistry on paraffin-embedded sections from 71 consecutive stage I-II SCCHN patients treated with curative RT. We detected bcl-2 protein in 21% of SCCHN studied. A suggestive association was observed between tobacco exposure and bcl-2 protein expression (P < 0.1); this association was stronger in those patients who failed primary RT (P = 0.03). Moreover, we documented a higher rate of bcl-2 immunoreactive tumors in postirradiated biopsies from relapsed patients than in preirradiated ones (P = 0.03). In both univariate and multivariate analyses, bcl-2 expression was the most important indicator for disease-free survival (P = 0.08 and P = 0.01, respectively) and overall survival (P = 0.004 and P = 0.05) within 5 years of RT. The present study indicates that the proto-oncogene bcl-2 is abnormally expressed in some SCCHN, and its expression may prove to be a useful tool in selecting patients for conventional RT with clear prognostic implications.
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影响因子：
11.2
作者：
M. Dole;G. Núñez;Audrea K. Merchant;J. Maybaum;C. Rode;C. Bloch;V. Castle
通讯作者：
M. Dole;G. Núñez;Audrea K. Merchant;J. Maybaum;C. Rode;C. Bloch;V. Castle
bcl2 原癌基因在神经母细胞瘤和其他人类神经源肿瘤细胞系中的差异表达。
影响因子：
11.2
作者：
Reed,JC;Meister,L;Tanaka,S;Cuddy,M;Yum,S;Geyer,C;Pleasure,D
通讯作者：
Pleasure,D
人神经母细胞瘤中 Bcl-2 癌蛋白的免疫组织化学分析。
DOI：
--
发表时间：
1995
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
--
作者：
Krajewski,S;Chatten,J;Hanada,M;Reed,JC
通讯作者：
Reed,JC
DOI：
10.1016/0360-3016(88)90297-0
发表时间：
1988-09-01
影响因子：
7
作者：
WEICHSELBAUM, RR;BECKETT, MA;DRITSCHILO, A
通讯作者：
DRITSCHILO, A
影响因子：
56.9
作者：
TSUJIMOTO, Y;YUNIS, J;CROCE, CM
通讯作者：
CROCE, CM