Androgenic regulation of ventral epithelial bud number and pattern in mouse urogenital sinus.
Androgenic regulation of ventral epithelial bud number and pattern in mouse urogenital sinus.
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DOI：
10.1002/dvdy.22169
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发表时间：
2010-02
影响因子：
2.5
通讯作者：
Peterson, Richard E.
中科院分区：
文献类型：
--
作者：
Allgeier, Sarah H.;Lin, Tien-Min;Moore, Robert W.;Vezina, Chad M.;Abler, Lisa L.;Peterson, Richard E.
关键词：
对照雄性小鼠的腹侧泌尿生殖窦（UGS）在出生时具有两排3 - 4个前列腺芽，但雄激素如何调节腹侧芽（VB）的数量和分布模式尚不清楚。两性的VB似乎是前列腺芽和尿道芽的混合体。来自睾丸女性化（Tfm）雄性小鼠和暴露于抗雄激素（氟他胺）的小鼠的UGS具有小的VB，这表明一些VB的起始是雄激素非依赖性的。睾丸女性化雄性小鼠通常被认为对雄激素完全不敏感，然而它们的UGS对5α - 二氢睾酮（DHT）有反应。在最小和正常雄性雄激素信号传导下，VB（6 - 8个）通常在左右轴上呈双峰分布。然而，对照雌性小鼠和暴露于DHT的睾丸女性化雄性小鼠有13 - 14个VB，其左右分布相当均匀。这些结果表明，随着雄激素信号从最小程度增加，VB的数量和分布呈双相反应，并且雄激素调节芽的特化。选择性出芽抑制剂2,3,7,8 - 四氯二苯并 - 对 - 二恶英（TCDD）导致VB完全不发育需要高的雄激素信号。
The ventral urogenital sinus (UGS) of control male mice has two rows of 3–4 prostatic buds at birth, but how androgens regulate ventral bud (VB) number and patterning is unclear. VBs in both sexes appeared to be a mixture of prostatic and urethral buds. UGSs from Tfm male and antiandrogen (flutamide)-exposed mice had small VBs, suggesting that initiation of some VBs is androgen independent. Tfm male mice are widely considered completely androgen insensitive yet their UGSs were 5α-dihydrotestosterone (DHT)-responsive. VBs (6–8) were generally distributed bimodally on the left-right axis at both minimal and normal male androgen signaling. Yet control females and DHT-exposed Tfm males had 13–14 VBs, whose left-right distribution was fairly uniform. These results suggest that VB number and distribution respond biphasically as androgen signaling increases from minimal, and that androgens regulate bud specification. Complete VB agenesis by the selective budding inhibitor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) required high androgen signaling.
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影响因子：
4
作者：
LASNITZKI, I;MIZUNO, T
通讯作者：
MIZUNO, T
影响因子：
2.5
作者：
Chen, H;Mutton, LN;Bieberich, CJ
通讯作者：
Bieberich, CJ
影响因子：
2.9
作者：
Kuslak, Sheri L.;Marker, Paul C.
通讯作者：
Marker, Paul C.
影响因子：
4.8
作者：
Bieberich, CJ;Fujita, K;Jay, G
通讯作者：
Jay, G
DOI：
10.1007/bf00300584
发表时间：
1984-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
KOBAYASHI, S
通讯作者：
KOBAYASHI, S