Structural Relationship between Cerebral Gray and White Matter Alterations in Degenerative Cervical Myelopathy.
Structural Relationship between Cerebral Gray and White Matter Alterations in Degenerative Cervical Myelopathy.
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DOI：
10.3390/tomography9010025
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发表时间：
2023-01-31
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影响因子：
--
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退行性脊髓型颈椎病(DCM)患者接受适应性棘上改变。然而，皮质下白质的变化如何反映灰质的丢失仍不清楚。目前的研究调查了DCM患者灰质和皮质下白质改变之间的相互关系。对44名患者和17名健康对照组的灰质皮质厚度以及皮质下白质的细胞内体积分数(ICVF)进行了评估。结果表明，感觉运动和疼痛相关区域的皮质变薄与更严重的DCM症状有关。研究患者大脑皮质下白质的ICVF值明显低于HCS患者。左侧中央前回(r=0.5715，p<；结果显示，在本组患者中，左侧边缘上回(r=0.3847，p=0.0099)、左侧中央后回(r=0.5195，p=0.0003)、右侧额上回(r=0.3266，p=0.0305)、右侧尾侧(r=0.4749，p=0.0011)和头侧扣带前回(r=0.3927，p=0.0084)的脑血管流量与皮质厚度呈正相关，而与皮质厚度的相关性不显著。目前的研究结果表明，扩张型心肌病可能引起广泛的灰质改变和皮质下神经突起的丢失，这些可能是反映扩张型心肌病病理的潜在成像生物标志物。
Patients with degenerative cervical myelopathy (DCM) undergo adaptive supraspinal changes. However, it remains unknown how subcortical white matter changes reflect the gray matter loss. The current study investigated the interrelationship between gray matter and subcortical white matter alterations in DCM patients. Cortical thickness of gray matter, as well as the intra-cellular volume fraction (ICVF) of subcortical whiter matter, were assessed in a cohort of 44 patients and 17 healthy controls (HCs). The results demonstrated that cortical thinning of sensorimotor and pain related regions is associated with more severe DCM symptoms. ICVF values of subcortical white matter underlying the identified regions were significantly lower in study patients than in HCs. The left precentral gyrus (r = 0.5715, p < 0.0001), the left supramarginal gyrus (r = 0.3847, p = 0.0099), the left postcentral gyrus (r = 0.5195, p = 0.0003), the right superior frontal gyrus (r = 0.3266, p = 0.0305), and the right caudal (r = 0.4749, p = 0.0011) and rostral anterior cingulate (r = 0.3927, p = 0.0084) demonstrated positive correlations between ICVF and cortical thickness in study patients, but no significant correlations between ICVF and cortical thickness were observed in HCs. Results from the current study suggest that DCM may cause widespread gray matter alterations and underlying subcortical neurite loss, which may serve as potential imaging biomarkers reflecting the pathology of DCM.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.8
作者：
Bergsland, Niels;Lagana, Maria Marcella;Rovaris, Marco
通讯作者：
Rovaris, Marco
使用扩散光谱成像（DSI）检测与退化性宫颈脊髓病有关的大脑重组。
DOI：
10.1016/j.jocn.2021.01.011
发表时间：
2021-04
期刊：
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
影响因子：
--
作者：
Wang C;Holly LT;Oughourlian T;Yao J;Raymond C;Salamon N;Ellingson BM
通讯作者：
Ellingson BM
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
11.1
作者：
Wang, Chencai;Ellingson, Benjamin M.;Oughourlian, Talia C.;Salamon, Noriko;Holly, Langston T.
通讯作者：
Holly, Langston T.