The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation.
The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation.
复制标题
运动对骨髓间充质干细胞命运的影响：深入了解机械调节和骨形成
DOI：
10.1186/s13578-021-00601-9
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发表时间：
2021-05-17
影响因子：
7.5
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Sun Y;Yuan Y;Wu W;Lei L;Zhang L
骨髓间充质干细胞（BMSC）是指具有自我更新能力的异质细胞群。 BMSCs具有多向分化潜能，在特定的微环境或机械调节下可以分化为软骨细胞、成骨细胞和脂肪细胞。 BMSCs的活性与骨质量密切相关。先前的研究表明，骨髓间充质干细胞及其谱系分化的后代（例如成骨细胞）和骨细胞在骨中具有机械敏感性。因此，本综述的目的是讨论 BMSC 如何感知机械刺激产生的这些普遍信号，以及细胞如何对这些信号做出反应。近年来的研究表明，运动对骨髓间充质干细胞的迁移、增殖和分化有显着影响，从而有助于增加骨量。这种调节是通过各种交叉信号通路实现的，包括 RhoA/Rock、IFG、BMP 和 Wnt 信号通路。 BMSC 的机械反应还为通过适当的锻炼维持骨骼健康提供指导。本综述将总结运动/机械负荷对 BMSC 活动的调节作用。此外，还将讨论许多控制 MSC 向成骨或脂肪细胞分化的命运的信号通路。对 BMSC 机械反应的理解为转化医学奠定了基础。
Bone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and can differentiate into chondrocytes, osteoblasts, and adipocytes under specific microenvironment or mechanical regulation. The activities of BMSCs are closely related to bone quality. Previous studies have shown that BMSCs and their lineage-differentiated progeny (for example, osteoblasts), and osteocytes are mechanosensitive in bone. Thus, a goal of this review is to discuss how these ubiquious signals arising from mechanical stimulation are perceived by BMSCs and then how the cells respond to them. Studies in recent years reported a significant effect of locomotion on the migration, proliferation and differentiation of BMSCs, thus, contributing to our bone mass. This regulation is realized by the various intersecting signaling pathways including RhoA/Rock, IFG, BMP and Wnt signalling. The mechanoresponse of BMSCs also provides guidance for maintaining bone health by taking appropriate exercises. This review will summarize the regulatory effects of locomotion/mechanical loading on BMSCs activities. Besides, a number of signalling pathways govern MSC fate towards osteogenic or adipocytic differentiation will be discussed. The understanding of mechanoresponse of BMSCs makes the foundation for translational medicine.
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影响因子：
3.7
作者：
Arnsdorf EJ;Tummala P;Jacobs CR
通讯作者：
Jacobs CR
影响因子：
2.4
作者：
Arnsdorf, Emily J.;Tummala, Padmaja;Castillo, Alesha B.;Zhang, Fan;Jacobs, Christopher R.
通讯作者：
Jacobs, Christopher R.
影响因子：
4.1
作者：
Casazza K;Hanks LJ;Hidalgo B;Hu HH;Affuso O
通讯作者：
Affuso O
影响因子：
4.8
作者：
Baker, J. M.;De Lisio, Michael;Parise, Gianni
通讯作者：
Parise, Gianni
影响因子：
6.2
作者：
Fuchs, RK;Bauer, JJ;Snow, CM
通讯作者：
Snow, CM