Dissociations among daytime sleepiness, nighttime sleep, and cognitive status in Parkinson's disease.
Dissociations among daytime sleepiness, nighttime sleep, and cognitive status in Parkinson's disease.
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DOI：
10.1016/j.parkreldis.2013.05.006
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发表时间：
2013-09
影响因子：
4.1
通讯作者：
Stebbins GT
中科院分区：
文献类型：
--
作者：
Goldman JG;Ghode RA;Ouyang B;Bernard B;Goetz CG;Stebbins GT
白天和夜间睡眠障碍和认知障碍经常发生在帕金森病（PD），但很少有人知道这些非运动并发症的相互依赖性。因此，我们研究了PD患者白天过度嗜睡、夜间睡眠质量和认知障碍（包括严重程度和特定认知缺陷）之间的关系。93例PD患者接受了临床和神经心理学评估，包括埃普沃思嗜睡量表（ESS）和匹兹堡睡眠质量指数（PSQI）。根据运动障碍协会最近提出的PD-MCI和PDD标准，将患者分为正常认知（PD-NC）、轻度认知障碍（PD-MCI）或痴呆（PDD）。研究了睡眠和认知测量与PD认知组之间的关系。PD队列包括PD-NC（n = 28）、PD-MCI（n = 40）和PDD（n = 25）患者。ESS评分，作为白天嗜睡的衡量标准，在认知功能受损的PD患者，特别是PDD患者中显著更差（p = 0.005）。ESS评分与简易精神状态检查评分以及注意/工作记忆、执行功能、记忆和视觉空间功能的认知领域评分显著相关。相比之下，PSQI评分作为夜间睡眠质量的衡量标准，在认知组之间既没有差异，也没有与任何认知指标相关。PD患者的日间嗜睡（而非夜间睡眠问题）与PD患者的认知障碍相关，尤其是在痴呆、注意力/工作记忆、执行功能、记忆和视觉空间缺陷的情况下。夜间睡眠问题的存在在PD认知谱中是普遍存在的，从正常认知到痴呆，并且与认知领域的认知障碍或缺陷无关。
Daytime and nighttime sleep disturbances and cognitive impairment occur frequently in Parkinson’s disease (PD), but little is known about the interdependence of these non-motor complications. Thus, we examined the relationships among excessive daytime sleepiness, nighttime sleep quality and cognitive impairment in PD, including severity and specific cognitive deficits. Ninety-three PD patients underwent clinical and neuropsychological evaluations including the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). Patients were classified as having normal cognition (PD-NC), mild cognitive impairment (PD-MCI), or dementia (PDD) using recently proposed Movement Disorder Society PD-MCI and PDD criteria. Relationships between the sleep and cognitive measures and PD cognitive groups were examined. The PD cohort included PD-NC (n=28), PD-MCI (n=40), and PDD (n=25) patients. ESS scores, as a measure of daytime sleepiness, were significantly worse (p=0.005) in cognitively impaired PD patients, particularly PDD patients. ESS scores correlated significantly with Mini-Mental State Examination scores and also with cognitive domain scores for attention/working memory, executive function, memory, and visuospatial function. In contrast, PSQI scores, as a measure of nighttime sleep quality, neither differed among cognitive groups nor correlated with any cognitive measures. Daytime sleepiness in PD, but not nighttime sleep problems, is associated with cognitive impairment in PD, especially in the setting of dementia, and attention/working memory, executive function, memory, and visuospatial deficits. The presence of nighttime sleep problems is pervasive across the PD cognitive spectrum, from normal cognition to dementia, and is not independently associated with cognitive impairment or deficits in cognitive domains.
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DOI：
10.1002/mds.25062
发表时间：
2012-08
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Goldman JG;Weis H;Stebbins G;Bernard B;Goetz CG
通讯作者：
Goetz CG
影响因子：
8.6
作者：
Naismith, Sharon L.;Terpening, Zoe;Lewis, Simon J. G.
通讯作者：
Lewis, Simon J. G.
影响因子：
8.6
作者：
Paus, S;Brecht, HM;Wüllner, U
通讯作者：
Wüllner, U
DOI：
10.1017/s1355617711001482
发表时间：
2012-01-01
影响因子：
2.6
作者：
Stavitsky, Karina;Neargarder, Sandy;Cronin-Golomb, Alice
通讯作者：
Cronin-Golomb, Alice
影响因子：
4.8
作者：
Merlino, G.;Piani, A.;Valente, M.
通讯作者：
Valente, M.