The native cell population does not contribute to central-third graft healing at 6, 12, or 26 weeks in the rabbit patellar tendon.
The native cell population does not contribute to central-third graft healing at 6, 12, or 26 weeks in the rabbit patellar tendon.
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DOI：
10.1002/jor.22261
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发表时间：
2013-04
影响因子：
2.8
通讯作者：
Shearn, Jason T.
中科院分区：
文献类型：
--
作者：
Kinneberg, Kirsten R. C.;Galloway, Marc T.;Butler, David L.;Shearn, Jason T.
研究人员还不了解内在肌腱细胞在肌腱-骨附着点愈合中的作用。因此，我们的第一个目标是了解天然细胞群如何影响自体肌腱移植物在中央三分之一髌腱缺损部位的结合。为此，我们在成年新西兰白色兔中对比了脱细胞髌腱自体移植物（dcPTA）和髌腱自体移植物（PTA）修复的组织化学和生物力学特性。认识到许多动物模型中的软组织需要长达26周才能融入骨中，我们的第二个目标是研究恢复时间如何影响附着点形成和移植组织生物力学特性。因此，我们在术后6、12和26周检查了移植物结构和力学。我们的研究结果表明，保持天然细胞群在6周，12周或26周时没有产生组织化学或生物力学方面的益处。这些发现表明PTA愈合更多地由外在而非内在细胞机制介导。此外，虽然修复组织的生物力学性能通常在术后6 - 12周增加，但在26周内没有进一步改善。
Investigators do not yet understand the role of intrinsic tendon cells in healing at the tendon-to-bone enthesis. Therefore, our first objective was to understand how the native cell population influences tendon autograft incorporation in the central-third patellar tendon defect site. To do this, we contrasted the histochemical and biomechanical properties of de-cellularized patellar tendon autograft (dcPTA) and patellar tendon autograft (PTA) repairs in the skeletally mature New Zealand white rabbit. Recognizing that soft tissues in many animal models require up to 26 weeks to incorporate into bone, our second objective was to investigate how recovery time affects enthesis formation and graft tissue biomechanical properties. Thus, we examined graft structure and mechanics at 6, 12, and 26 weeks post-surgery. Our results showed that maintaining the native cell population produced no histochemical or biomechanical benefit at 6, 12 or 26 weeks. These findings suggest that PTA healing is mediated more by extrinsic rather than intrinsic cellular mechanisms. Moreover, while repair tissue biomechanical properties generally increased from 6 to 12 weeks after surgery, no further improvements were noted up to 26 weeks.
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影响因子：
2.4
作者：
Newsham-West, R.;Nicholson, H.;Milburn, P.
通讯作者：
Milburn, P.
DOI：
10.2106/00004623-197456020-00002
发表时间：
1974-01-01
影响因子：
5.3
作者：
NOYES, FR;DELUCAS, JL;TORVIK, PJ
通讯作者：
TORVIK, PJ
影响因子：
4.7
作者：
Stringham, DR;Pelmas, CJ;Marcus, RL
通讯作者：
Marcus, RL
DOI：
10.2106/00004623-200207000-00005
发表时间：
2002-07-01
影响因子：
5.3
作者：
Martinek, V;Latterman, C;Huard, J
通讯作者：
Huard, J
影响因子：
3.8
作者：
Scheffler, S. U.;Unterhauser, F. N.;Weiler, A.
通讯作者：
Weiler, A.