Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2.
Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2.
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DOI：
10.1016/j.reprotox.2012.10.001
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Zalups RK
中科院分区：
文献类型：
--
作者：
Bridges CC;Joshee L;Zalups RK
甲基汞是一种流行的环境毒物，可能对发育中的胎儿产生有害影响。以往的研究表明，多药耐药相关蛋白2(MRP2)参与了汞离子的肾脏和肝脏输出。因此，我们推测，MRP2也参与了胎盘滋养层细胞和胎儿组织汞离子的输出。为了验证这一假设，我们评估了孕期Wistar和tr-(mrp2缺乏)大鼠暴露于单剂量甲基汞中汞离子的处置情况。大鼠肾组织(皮质和外髓外纹)、肝脏、血液、羊水、子宫、胎盘和胎儿的汞含量显著高于Wistar大鼠。在Wistar大坝中，尿汞和粪便中汞的排除量比在tr大坝中要大。因此，我们的研究结果表明，MRP2可能参与了甲基汞暴露后母体和胎儿器官汞离子的输出。
Methylmercury is a prevalent environmental toxicant that can have deleterious effects on a developing fetus. Previous studies indicate that the multidrug resistance-associated protein 2 (Mrp2) is involved in renal and hepatic export of mercuric ions. Therefore, we hypothesize that Mrp2 is also involved in export of mercuric ions from placental trophoblasts and fetal tissues. To test this hypothesis, we assessed the disposition of mercuric ions in pregnant Wistar and TR– (Mrp2-deficient) rats exposed to a single dose of methylmercury. The amount of mercury in renal tissues (cortex and outer stripe of outer medulla), liver, blood, amniotic fluid, uterus, placentas and fetuses was significantly greater in TR– rats than in Wistar rats. Urinary and fecal elimination of mercury was greater in Wistar dams than in TR– dams. Thus, our findings suggest that Mrp2 may be involved in the export of mercuric ions from maternal and fetal organs following exposure to methylmercury.
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