Shift work and chronic disease: the epidemiological evidence.

Shift work and chronic disease: the epidemiological evidence.
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DOI:
10.1093/occmed/kqr001
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发表时间:
2011-03
期刊:
Occupational medicine (Oxford, England)
影响因子:
--
通讯作者:
Travis RC
Travis RC
中科院分区:
其他
文献类型:
--
作者:
Wang XS;Armstrong ME;Cairns BJ;Key TJ;Travis RC

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参考文献

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背景 轮班工作,包括夜间工作,被认为会增加患慢性疾病的风险,包括癌症、心血管疾病 (CVD)、代谢综合征和糖尿病。最近对与这些假设相关的证据的审查主要集中在特定疾病或潜在机制上,但尚未发表有关轮班工作和慢性病的当前数据的一般摘要。方法 在手动搜索参考文献列表的帮助下,检索 2009 年 12 月 31 日之前在 PubMed 中索引的系统和批判性评论以及最近的原始研究。综述的主要结论和最近研究的主要结果以文本和表格形式呈现。结果 已发表的证据对于夜间工作与乳腺癌之间的不利关联具有提示性,但并非决定性的,但对于其他部位的癌症和所有癌症的总和而言,证据有限且不一致。轮班工作与心血管疾病、代谢综合征和糖尿病风险相关的研究结果也表明了不良关系,但并不能得出结论。结论 研究暴露和结果的异质性以及对积极但不显着的结果的强调使得很难得出一般性结论。其他疾病终点和研究人群需要更多数据。
Background Shift work, including night work, has been hypothesized to increase the risk of chronic diseases, including cancer, cardiovascular disease (CVD), metabolic syndrome and diabetes. Recent reviews of evidence relating to these hypotheses have focussed on specific diseases or potential mechanisms, but no general summary of the current data on shift work and chronic disease has been published. Methods Systematic and critical reviews and recent original studies indexed in PubMed prior to 31 December 2009 were retrieved, aided by manual searches of reference lists. The main conclusions from reviews and principle results from recent studies are presented in text and tables. Results Published evidence is suggestive but not conclusive for an adverse association between night work and breast cancer but limited and inconsistent for cancers at other sites and all cancers combined. Findings on shift work, in relation to risks of CVD, metabolic syndrome and diabetes are also suggestive but not conclusive for an adverse relationship. Conclusions Heterogeneity of study exposures and outcomes and emphasis on positive but non-significant results make it difficult to draw general conclusions. Further data are needed for additional disease endpoints and study populations.
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