Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins.
Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins.
复制标题
DOI：
10.1155/2015/921274
复制
发表时间：
2015
影响因子：
4.3
通讯作者：
Huffman FG
中科院分区：
文献类型：
--
作者：
Cheema AK;Li T;Liuzzi JP;Zarini GG;Dorak MT;Huffman FG
本研究的目的是评估PPARGC 1A多态性与非洲裔美国人和海地裔美国人2型糖尿病（T2D）风险相关性的差异。病例对照研究包括生活在南佛罗里达的年龄>30岁、自我认定的海地裔美国人（n = 110例病例和n = 116例对照）和非洲裔美国人（n = 124例病例和n = 122例对照），患有和不患有T2 D。校正后的Logistic回归分析显示，SNP rs7656250（OR = 0.22，P = 0.005）和rs4235308（OR = 0.42，P = 0.026）与海地裔美国人的T2D具有保护性相关性。然而，在非裔美国人中，rs4235308与T2D显示出显著的风险相关性（OR = 2.53，P = 0.028）。按性别分层后，在海地裔美国人中，rs4235308（OR = 0.38，P = 0.026）和rs7656250 rs7656250（OR = 0.23，P = 0.006）在女性中显示与T2D的保护性关联，而在非洲裔美国男性中，rs7656250对T2D具有统计学显著的保护作用（OR = 0.37，P = 0.043）。在海地裔美国人和非洲裔美国人之间观察到的PPARGC1A SNP、rs4235308和rs7656250与T2D的遗传关联趋势指出了黑人种族的差异，并保证了更大样本量的复制研究。
The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) and African Americans (n = 124 cases and n = 122 controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, P = 0.005) and rs4235308 (OR = 0.42, P = 0.026) showed protective association with T2D in Haitian Americans. In African Americans, however, rs4235308 showed significant risk association with T2D (OR = 2.53, P = 0.028). After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043). The trends observed for genetic association of PPARGC1A SNPs, rs4235308, and rs7656250 for T2D between Haitian Americans and African Americans point out differences in Black race and warrant replicative study with larger sample size.
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人类2型糖尿病胰岛中PPARGC1A的表观遗传调节以及对胰岛素分泌的影响。
影响因子：
8.2
作者：
Ling, C.;Del Guerra, S.;Lupi, R.;Ronn, T.;Granhall, C.;Luthman, H.;Masiello, P.;Marchetti, P.;Groop, L.;Del Prato, S.
通讯作者：
Del Prato, S.
影响因子：
120.7
作者：
Narayan, KMV;Boyle, JP;Williamson, DF
通讯作者：
Williamson, DF
影响因子：
8.2
作者：
Hara, K;Tobe, K;Kadowaki, T
通讯作者：
Kadowaki, T
影响因子：
7.1
作者：
Fernandez-Marcos, Pablo J.;Auwerx, Johan
通讯作者：
Auwerx, Johan
影响因子：
4.8
作者：
Miura, S;Kai, Y;Ezaki, O
通讯作者：
Ezaki, O