The structure of cell-matrix adhesions: the new frontier.
The structure of cell-matrix adhesions: the new frontier.
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DOI：
10.1016/j.ceb.2011.12.001
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发表时间：
2012-02
影响因子：
7.5
通讯作者：
Horwitz, Alan Rick
中科院分区：
文献类型：
--
作者：
Hanein, Dorit;Horwitz, Alan Rick
Adhesions between the cell and the extracellular matrix (ECM) are mechanosensitive multi-protein assemblies that transmit force across the cell membrane and regulate biochemical signals in response to the chemical and mechanical environment. These combined functions in force transduction, signaling and mechanosensing contribute to cellular phenotypes that span development, homeostasis and disease. These adhesions form, mature and disassemble in response to actin organization and physical forces that originate from endogenous myosin activity or external forces by the extracellular matrix. Despite advances in our understanding of the protein composition, interactions and regulation, our understanding of matrix adhesion structure and organization, how forces affect this organization, and how these changes dictate specific signaling events is limited. Insights across multiple structural levels are acutely needed to elucidate adhesion structure and ultimately the molecular basis of signaling and mechanotransduction. Here we describe the challenges and recent advances and prospects for unraveling the structure of cell-matrix adhesions and their response to force.
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影响因子：
9.2
作者：
Byron, Adam;Morgan, Mark R.;Humphries, Martin J.
通讯作者：
Humphries, Martin J.
影响因子：
3.3
作者：
Deakin NO;Turner CE
通讯作者：
Turner CE
DOI：
10.1083/jcb.20.2.199
发表时间：
1964-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
CURTIS AS
通讯作者：
CURTIS AS
粘着斑蛋白在三维细胞运动中的独特作用。
影响因子：
21.3
作者：
Fraley, Stephanie I.;Feng, Yunfeng;Krishnamurthy, Ranjini;Kim, Dong-Hwee;Celedon, Alfredo;Longmore, Gregory D.;Wirtz, Denis
通讯作者：
Wirtz, Denis
影响因子：
64.5
作者：
BURRIDGE, K;FERAMISCO, JR
通讯作者：
FERAMISCO, JR