Adhesion signalling complexes.
Adhesion signalling complexes.
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DOI：
10.1016/j.cub.2010.10.059
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发表时间：
2010-12-21
期刊：
影响因子：
9.2
通讯作者：
Humphries, Martin J.
中科院分区：
文献类型：
--
作者：
Byron, Adam;Morgan, Mark R.;Humphries, Martin J.
后生动物的细胞间通讯不仅需要自分泌、旁分泌和外分泌信号系统，而且还依赖于编码在细胞外基质（ECM）中的结构和位置信息。组织中的大多数细胞在结构上和功能上与其周围的ECM以高度有组织的方式整合，涉及数千个动态连接。在这些连接的细胞内表面上，粘附受体-主要是整联蛋白和多配体蛋白聚糖-将细胞骨架连接到质膜并将细胞质信号传导事件区室化，而在细胞外表面上，相同的受体指导和组织ECM本身的沉积。粘附受体通过将可变形的ECM束缚在收缩性细胞骨架上来双向传递穿过质膜的机械力（图1），并且它们将ECM的形貌和组成转化为决定行为的化学信号。粘附受体的近膜功能反过来触发细胞内的远端过程，例如细胞运动方向的改变和基因转录的调节，以及细胞外的长期影响，例如ECM网络的构建和随后的高级组织结构的成形。鉴于粘附的多样性和基本作用，可以理解的是，粘附受体的参与已被报道改变了几乎所有主要信号通路的流量。
Intercellular communication in metazoa not only requires autocrine, paracrine and exocrine signalling systems, but it also relies on the structural and positional information encoded in extracellular matrices (ECMs). Most cells in tissues are structurally and functionally integrated with their surrounding ECM in a highly organised manner involving thousands of dynamic connections. On the intracellular face of these linkages, adhesion receptors — principally integrins and syndecans — link the cytoskeleton to the plasma membrane and compartmentalise cytoplasmic signalling events, whereas at the extracellular face the same receptors direct and organise the deposition of the ECM itself. Adhesion receptors transduce mechanical force bidirectionally across the plasma membrane by tethering variably deformable ECMs to the contractile cytoskeleton (Figure 1), and they translate the topography and composition of the ECM into chemical signals that determine behaviour. The membrane-proximal functions of adhesion receptors in turn trigger distal processes within cells, such as alterations in the direction of cell movement and the regulation of gene transcription, and long-range effects outside cells, such as the construction of ECM networks and consequent shaping of higher-order tissue structure. Given the diverse and fundamental roles attributed to adhesion, it is understandable that adhesion receptor engagement has been reported to alter the flux through virtually all major signalling pathways.
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影响因子：
7.5
作者：
Vogel V;Sheetz MP
通讯作者：
Sheetz MP
DOI：
10.1038/nrm2957
发表时间：
2010-09
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.3
作者：
Humphries JD;Byron A;Bass MD;Craig SE;Pinney JW;Knight D;Humphries MJ
通讯作者：
Humphries MJ
影响因子：
4
作者：
Humphries JD;Byron A;Humphries MJ
通讯作者：
Humphries MJ
影响因子：
21.3
作者：
Zamir, E;Katz, M;Geiger, B
通讯作者：
Geiger, B