SIALYL LEWISx AS A TUMOR-ASSOCIATED CARBOHYDRATE ANTIGEN IN BREAST CANCER
SIALYL LEWISx AS A TUMOR-ASSOCIATED CARBOHYDRATE ANTIGEN IN BREAST CANCER
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SIALYL LEWISx 作为乳腺癌中的肿瘤相关碳水化合物抗原
DOI：
10.3919/ringe1963.50.847
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
M. Ifuku
中科院分区：
文献类型：
--
作者：
T. Nakagoe;H. Kusano;K. Kimino;Y. Tagawa;K. Kawahara;H. Ayabe;T. Shimoyama;T. Miura;M. Ifuku
手术乳腺癌进行了血清学和免疫组化评价的唾液酸化Lewisx抗原作为肿瘤相关的，其中一种新的单克隆抗体CSLEX 1与唾液酸化Lewisx抗原反应被使用。在30例乳腺癌患者血清中，SailaylLewisx的阳性率为30%（9/30），优于CEA、CA 19 -9、CA 15 -3和SLX等其他肿瘤标志物。按临床分期，Ⅰ、Ⅱ、Ⅲ、Ⅳ期的阳性率分别为20.0%、37.5%、40.0%和50.0%。41例乳腺癌组织和正常乳腺导管上皮中唾液酸化Lewisx的表达率分别为95.5%（21/22）和65.9%（27/41）。虽然唾液酸化Lewisx抗原的免疫组化表达表明癌症特异性较低，但在I期和II期癌症患者血清中获得了较高的阳性率。提示唾液酸化Lewisx抗原可作为乳腺癌的肿瘤相关抗原。
Operative breast cancers were subjected to a serological and immunohistochemical evaluation of sialyl Lewisx antigen as a tumor-associated one, where a new monoclonal antibody CSLEX1 which reacts with sialyl Lewisx antigen was used. Percent positive of sailayl Lewisx in sera of 30 patients with breast cancer was 30%(9/30), which was better than those of any other tumor markers such as CEA, CA19-9, CA15-3 and SLX. Percent positives, according to clinical stages, were 20.0%, 37.5%, 40.0% and 50.0% in stage I, II, III and IV respectively. Immunohistochemically, the expression of a sialyl Lewisx in the normal ductal epithelium and carcinoma cells of 41 breast cancers demonstrated 95.5%(21/22) and 65.9%(27/41) respectively. Although the immunohistochemical experssion of sialyl Lewisx antigen indicated a low cancer specificity, comparatively high positive rates in stage I and II were obtained in sera of cancer patients. It has been suggested that sialyl Lewisx antigen is useful as a tumor-associatd antigen in breast cancers.
DOI：
10.1016/s0021-9258(19)45389-1
发表时间：
1982-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
通讯作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
影响因子：
11.2
作者：
K. Fukushima;M. Hirota;P. Terasaki;A. Wakisaka;H. Togashi;D. Chia;N. Suyama;Y. Fukushi;E. Nudelman;S. Hakomori
通讯作者：
K. Fukushima;M. Hirota;P. Terasaki;A. Wakisaka;H. Togashi;D. Chia;N. Suyama;Y. Fukushi;E. Nudelman;S. Hakomori
双岩藻神经节苷脂 (VI3NeuAcV3III3Fuc2nLc6) 在正常和肿瘤组织中的位置和分布由其单克隆抗体 FH6 确定。
影响因子：
11.2
作者：
Fukushi,Y;Kannagi,R;Hakomori,S;Shepard,T;Kulander,BG;Singer,JW
通讯作者：
Singer,JW