Microalgal biofactories: a promising approach towards sustainable omega-3 fatty acid production.
Microalgal biofactories: a promising approach towards sustainable omega-3 fatty acid production.
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DOI：
10.1186/1475-2859-11-96
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发表时间：
2012-07-25
影响因子：
6.4
通讯作者：
Schenk PM
中科院分区：
文献类型：
--
作者：
Adarme-Vega TC;Lim DK;Timmins M;Vernen F;Li Y;Schenk PM
欧米茄-3脂肪酸二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)提供了显著的健康益处，这导致了作为膳食补充剂的消费量增加。Omega-3脂肪酸EPA和DHA存在于动物、转基因植物、真菌和许多微生物中，但通常是从富含脂肪的鱼类中提取的，这给全球鱼类资源带来了额外的压力。作为初级生产者，许多海洋微藻富含EPA(C20：5)和DHA(C22：6)，是omega-3脂肪酸的潜在来源。几种异养微藻已经被用作商业上生产omega-3脂肪酸的生物工厂，但近年来随着微藻被开发为生物燃料作物，人们对自养微藻产生了浓厚的兴趣。本文概述了微藻生物技术和用于开发omega-3脂肪酸EPA和DHA的生产平台。它涉及目前微藻作为水产养殖饲料和未来生物燃料作物的生物技术用途的影响，并探索代谢工程和选择性育种的潜在应用，以在自养微藻中积累大量omega-3脂肪酸。
Omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) provide significant health benefits and this has led to an increased consumption as dietary supplements. Omega-3 fatty acids EPA and DHA are found in animals, transgenic plants, fungi and many microorganisms but are typically extracted from fatty fish, putting additional pressures on global fish stocks. As primary producers, many marine microalgae are rich in EPA (C20:5) and DHA (C22:6) and present a promising source of omega-3 fatty acids. Several heterotrophic microalgae have been used as biofactories for omega-3 fatty acids commercially, but a strong interest in autotrophic microalgae has emerged in recent years as microalgae are being developed as biofuel crops. This paper provides an overview of microalgal biotechnology and production platforms for the development of omega-3 fatty acids EPA and DHA. It refers to implications in current biotechnological uses of microalgae as aquaculture feed and future biofuel crops and explores potential applications of metabolic engineering and selective breeding to accumulate large amounts of omega-3 fatty acids in autotrophic microalgae.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
3.9
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