The journey of resveratrol from yeast to human.

The journey of resveratrol from yeast to human.
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DOI:
10.18632/aging.100445
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发表时间:
2012-03
期刊:
Aging
影响因子:
--
通讯作者:
Schrauwen P
Schrauwen P
中科院分区:
其他
文献类型:
--
作者:
Timmers S;Auwerx J;Schrauwen P

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天然多酚化合物白藜芦醇最早发现于20世纪40年代。近年来,这种化合物重新引起了人们的兴趣,因为有几项发现表明白藜芦醇是一种有效的SIRT1激活剂,能够模拟热量限制的作用,并调节低等生物的寿命。鉴于世界范围内与年龄相关的代谢疾病的增加,白藜芦醇对人类新陈代谢和健康衰老的有益作用是目前研究的热点。
The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
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