New Developments in Cholinergic Imaging in Alzheimer and Lewy Body Disorders.
New Developments in Cholinergic Imaging in Alzheimer and Lewy Body Disorders.
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DOI：
10.1007/s40473-020-00221-6
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发表时间：
2020-12
影响因子：
1.7
通讯作者：
Bohnen NI
中科院分区：
文献类型：
--
作者：
Craig CE;Ray NJ;Müller MLTM;Bohnen NI
本文旨在回顾阿尔茨海默病和路易体帕金森病的胆碱能神经影像学的新趋势。随着空间上更精确的放射性配体的可用性，胆碱能成像的范围正在扩大，这些放射性配体允许评估以前较少识别的具有更密集胆碱能神经支配的皮质下和皮质结构。此外，MRI技术的进步，现在允许胆碱能前脑和脚桥核的定量结构或功能评估，这可能是非侵入性的预后预测。多模态成像方法，如PET-MRI或多配体PET，为胆碱能系统在局部和大规模神经网络水平上的动态和交互作用提供了新的见解。我们对胆碱能系统在年龄相关疾病中的异质性作用的理解正在发展。多模态成像方法，提供胆碱能系统的互补意见将是必要的，以阐明胆碱能变性对区域和大规模神经网络的影响，支持神经变性的临床症状表现。
This paper aims to review novel trends in cholinergic neuroimaging in Alzheimer and Lewy body parkinsonian disorders. The spectrum of cholinergic imaging is expanding with the availability of spatially more precise radioligands that allow assessment of previously less recognized subcortical and cortical structures with more dense cholinergic innervation. In addition, advances in MRI techniques now allow quantitative structural or functional assessment of both the cholinergic forebrain and the pedunculopontine nucleus, which may serve as non-invasive prognostic predictors. Multimodal imaging approaches, such as PET-MRI or multiligand PET offer new insights into the dynamic and interactive roles of the cholinergic system at both local and larger-scale neural network levels. Our understanding of the heterogeneous roles of the cholinergic system in age-related diseases is evolving. Multimodal imaging approaches that provide complimentary views of the cholinergic system will be necessary to shed light on the impact of cholinergic degeneration on regional and large-scale neural networks that underpin clinical symptom manifestation in neurodegeneration.
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