Cognition and Cerebrovascular Reactivity in Midlife Women With History of Preeclampsia and Placental Evidence of Maternal Vascular Malperfusion.
Cognition and Cerebrovascular Reactivity in Midlife Women With History of Preeclampsia and Placental Evidence of Maternal Vascular Malperfusion.
复制标题
具有先兆子痫病史和母体血管厌食症的胎盘史的中年女性的认知和脑血管反应性。
DOI：
10.3389/fnagi.2021.637574
复制
发表时间：
2021
影响因子：
4.8
通讯作者：
Catov JM
中科院分区：
文献类型：
--
作者：
Shaaban CE;Rosano C;Cohen AD;Huppert T;Butters MA;Hengenius J;Parks WT;Catov JM
背景：先兆子痫是脑小血管病（SVD）和痴呆的一个性别特异性危险因素，但原因尚不清楚。我们评估了母体血管灌注不良（MVM）（胎盘SVD的标志物）与有和无先兆子痫妇女的认知和脑SVD的关系。我们假设患有先兆子痫和MVM的女性在信息处理速度和执行功能方面表现最差。研究方法：女性（n = 45;平均10.5年产后;平均年龄：41岁; 42.2%黑人）被分类为先兆子痫-/MVM-、先兆子痫+/MVM-或先兆子痫+/MVM+。信息处理速度，执行功能和记忆进行了评估。在脑血管反应性（CVR; n = 22）的初步子研究中，通过动脉自旋标记MRI获得了室内空气呼吸和屏气诱导的高碳酸血症期间的脑血流量。使用非参数检验和回归模型来检验相关性。结果：组间认知差异在信息处理速度方面具有显著性（p = 0.02）;先兆子痫+/MVM+得分最低。除先兆子痫+/MVM+顶叶区域外，三组中所有区域的脑血流量从室内空气到屏气均增加（p = 0.12）。下顶叶CVR（从室内空气呼吸到屏气的变化较小）与较差的信息处理速度（部分ρ = 0.63，p = 0.005）和执行功能（ρ = 0.50，p = 0.03）相关，与先兆子痫/MVM状态无关。结论：与没有先兆子痫和MVM的女性相比，患有先兆子痫和MVM的中年女性的信息处理速度更差，并且可能具有钝化的顶叶CVR，这是一个对信息处理速度和执行功能很重要的区域。先兆子痫妇女的MVM是中年脑血管完整性的一个有希望的性别特异性指标。
Background: Preeclampsia is emerging as a sex-specific risk factor for cerebral small vessel disease (SVD) and dementia, but the reason is unknown. We assessed the relationship of maternal vascular malperfusion (MVM), a marker of placental SVD, with cognition and cerebral SVD in women with and without preeclampsia. We hypothesized women with both preeclampsia and MVM would perform worst on information processing speed and executive function. Methods: Women (n = 45; mean 10.5 years post-delivery; mean age: 41 years; 42.2% Black) were classified as preeclampsia-/MVM-, preeclampsia+/MVM-, or preeclampsia+/MVM+. Information processing speed, executive function, and memory were assessed. In a pilot sub-study of cerebrovascular reactivity (CVR; n = 22), cerebral blood flow during room-air breathing and breath-hold induced hypercapnia were obtained via arterial spin labeling MRI. Non-parametric tests and regression models were used to test associations. Results: Between-group cognitive differences were significant for information processing speed (p = 0.02); preeclampsia+/MVM+ had the lowest scores. Cerebral blood flow increased from room-air to breath-hold, globally and in all regions in the three groups, except the preeclampsia+/MVM+ parietal region (p = 0.12). Lower parietal CVR (less change from room-air breathing to breath-holding) was correlated with poorer information processing speed (partial ρ = 0.63, p = 0.005) and executive function (ρ = 0.50, p = 0.03) independent of preeclampsia/MVM status. Conclusion: Compared to women without preeclampsia and MVM, midlife women with both preeclampsia and MVM have worse information processing speed and may have blunted parietal CVR, an area important for information processing speed and executive function. MVM in women with preeclampsia is a promising sex-specific indicator of cerebrovascular integrity in midlife.
登录
查看更多内容
影响因子：
3.7
作者：
Gratton C;Sun H;Petersen SE
通讯作者：
Petersen SE
DOI：
10.1111/1471-0528.15040
发表时间：
2018-07
期刊：
BJOG : an international journal of obstetrics and gynaecology
影响因子：
--
作者：
Catov JM;Muldoon MF;Reis SE;Ness RB;Nguyen LN;Yamal JM;Hwang H;Parks WT
通讯作者：
Parks WT
DOI：
10.1111/1471-0528.16201
发表时间：
2020-03-31
影响因子：
5.8
作者：
Andolf, E.;Bladh, M.;Sydsjo, G.
通讯作者：
Sydsjo, G.
影响因子：
9.8
作者：
Fields JA;Garovic VD;Mielke MM;Kantarci K;Jayachandran M;White WM;Butts AM;Graff-Radford J;Lahr BD;Bailey KR;Miller VM
通讯作者：
Miller VM
影响因子：
4
作者：
De Silva TM;Faraci FM
通讯作者：
Faraci FM