Comparing natural and constrained movements: new insights into the visuomotor control of grasping.
Comparing natural and constrained movements: new insights into the visuomotor control of grasping.
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DOI：
10.1371/journal.pone.0001108
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发表时间：
2007-10-31
期刊：
影响因子：
3.7
通讯作者：
Castiello U
中科院分区：
文献类型：
--
作者：
Begliomini C;Caria A;Grodd W;Castiello U
神经生理学研究表明，在猕猴中，抓握相关的感觉运动转换是在连接前顶内沟（AIP区）与运动前区F5的回路中完成的。猕猴的单个单位记录表明，该回路中神经元的活动并不简单地与任何特定对象相关。相反，响应对应于用于抓握物体的最终手配置。虽然人类同源的这样一个电路已被确定，它的作用，规划和控制不同的把握配置尚未决定性地显示。我们使用功能性磁共振成像明确测试是否在这个网络内的活动变化取决于所采用的把握和刺激之间的一致性。要求受试者自然地伸向并抓住小或大的刺激（即，精确抓握，包括食指和拇指的相对，用于小尺寸的刺激和整个手抓握用于更大的刺激）或具有约束抓握（即，对于大刺激的精确抓握和对于小刺激的整只手抓握）。人类前顶内沟（hAIPS）是更积极的精确把握比独立的刺激大小的整个手把握。相反，背侧运动前皮质（dPMC）和初级运动皮质（M1）都受到所采用的抓握类型和刺激大小之间的关系的调节。hAIPS内的活动根据不同类型的抓握而调节的证明，以及人类背侧运动前皮质参与抓握规划和执行的证据，为当前关于视觉运动抓握神经基质的争论做出了重大贡献。人类。
Neurophysiological studies showed that in macaques, grasp-related sensorimotor transformations are accomplished in a circuit connecting the anterior intraparietal sulcus (area AIP) with premotor area F5. Single unit recordings of macaque indicate that activity of neurons in this circuit is not simply linked to any particular object. Instead, responses correspond to the final hand configuration used to grasp the object. Although a human homologue of such a circuit has been identified, its role in planning and controlling different grasp configurations has not been decisively shown. We used functional magnetic resonance imaging to explicitly test whether activity within this network varies depending on the congruency between the adopted grasp and the grasp called by the stimulus. Subjects were requested to reach towards and grasp a small or a large stimulus naturally (i.e., precision grip, involving the opposition of index finger and thumb, for a small size stimulus and a whole hand grasp for a larger stimulus) or with an constrained grasp (i.e., a precision grip for a large stimulus and a whole hand grasp for a small stimulus). The human anterior intraparietal sulcus (hAIPS) was more active for precise grasping than for whole hand grasp independently of stimulus size. Conversely, both the dorsal premotor cortex (dPMC) and the primary motor cortex (M1) were modulated by the relationship between the type of grasp that was adopted and the size of the stimulus. The demonstration that activity within the hAIPS is modulated according to different types of grasp, together with the evidence in humans that the dorsal premotor cortex is involved in grasp planning and execution offers a substantial contribution to the current debate about the neural substrates of visuomotor grasp in humans.
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影响因子：
2
作者：
Culham, JC;Danckert, SL;Goodale, MA
通讯作者：
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影响因子：
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作者：
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通讯作者：
Culham, Jody C.
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作者：
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通讯作者：
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