Gut microbes participate in food preference alterations during obesity.
Gut microbes participate in food preference alterations during obesity.
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DOI：
10.1080/19490976.2021.1959242
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
Everard A
中科院分区：
文献类型：
--
作者：
de Wouters d'Oplinter A;Rastelli M;Van Hul M;Delzenne NM;Cani PD;Everard A
下丘脑对食物摄入的调节在肥胖期间改变。负责对食物摄入的享乐反应的多巴胺能中皮质边缘系统也受到影响。肠道微生物是肥胖的另一个关键因素。因此，我们研究了肠道微生物群是否在导致肥胖的享乐性食物摄入改变中起因果作用。我们将来自瘦小鼠或饮食诱导的肥胖小鼠的粪便转移到受体小鼠中，并使用食物偏好测试比较供体和受体小鼠中对照和可口饮食（HFHS，高脂肪高蔗糖）的摄入来评估享乐食物摄入。在食物偏好测试期间，肥胖小鼠比瘦供体少吃58%的HFHS（p <0.0001），表明肥胖期间享乐食物摄入失调。引人注目的是，在肥胖期间由进食诱导的愉悦感的降低可通过肠道微生物群移植转移，因为肥胖肠道微生物群受体小鼠在食物偏好测试期间表现出类似的HFHS摄入减少（与瘦肠道微生物群受体小鼠相比减少40%，p <0.01）。这种效应与纹状体中多巴胺能标记物表达的变化趋势一致相关。我们还指出HFHS摄入量与副拟杆菌之间存在高度正相关性（p <0.0001），这可能代表了可能通过肠道-大脑轴参与享乐进食的潜在因素。我们进一步证明了肠道微生物在这种模式中发挥的关键作用，因为使用广谱抗生素消耗肠道微生物群也改变了瘦小鼠食物偏好测试期间的HFHS摄入量。总之，我们发现肠道微生物调节食物摄入的享乐方面。我们的数据表明，与肥胖相关的肠道微生物群改变参与了食物摄入的奖励和享乐成分的失调。这些数据提供的证据表明，肠道微生物可能是一个有趣的治疗目标，以解决与肥胖有关的享乐障碍。
Hypothalamic regulations of food intake are altered during obesity. The dopaminergic mesocorticolimbic system, responsible for the hedonic response to food intake, is also affected. Gut microbes are other key players involved in obesity. Therefore, we investigated whether the gut microbiota plays a causal role in hedonic food intake alterations contributing to obesity. We transferred fecal material from lean or diet-induced obese mice into recipient mice and evaluated the hedonic food intake using a food preference test comparing the intake of control and palatable diets (HFHS, High-Fat High-Sucrose) in donor and recipient mice. Obese mice ate 58% less HFHS during the food preference test (p < 0.0001) than the lean donors, suggesting a dysregulation of the hedonic food intake during obesity. Strikingly, the reduction of the pleasure induced by eating during obesity was transferable through gut microbiota transplantation since obese gut microbiota recipient mice exhibited similar reduction in HFHS intake during the food preference test (40% reduction as compared to lean gut microbiota recipient mice, p < 0.01). This effect was associated with a consistent trend in modifications of dopaminergic markers expression in the striatum. We also pinpointed a highly positive correlation between HFHS intake and Parabacteroides (p < 0.0001), which could represent a potential actor involved in hedonic feeding probably through the gut-to-brain axis. We further demonstrated the key roles played by gut microbes in this paradigm since depletion of gut microbiota using broad-spectrum antibiotics also altered HFHS intake during food preference test in lean mice. In conclusion, we discovered that gut microbes regulate hedonic aspects of food intake. Our data demonstrate that gut microbiota modifications associated with obesity participate in dysregulations of the reward and hedonic components of the food intake. These data provide evidence that gut microbes could be an interesting therapeutic target to tackle hedonic disorders related to obesity.
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DOI：
10.1186/1755-7682-3-24
发表时间：
2010-10-06
期刊：
International archives of medicine
影响因子：
--
作者：
Arias-Carrión O;Stamelou M;Murillo-Rodríguez E;Menéndez-González M;Pöppel E
通讯作者：
Pöppel E
影响因子：
5.2
作者：
Le Roy, Tiphaine;Debedat, Jean;Clement, Karine
通讯作者：
Clement, Karine
DOI：
10.1038/ismej.2014.45
发表时间：
2014-10
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
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DOI：
10.1126/science.aat5236
发表时间：
2018-09-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kaelberer MM;Buchanan KL;Klein ME;Barth BB;Montoya MM;Shen X;Bohórquez DV
通讯作者：
Bohórquez DV
DOI：
10.1523/jneurosci.2105-10.2010
发表时间：
2010-09-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Stice E;Yokum S;Blum K;Bohon C
通讯作者：
Bohon C