Disentangling interoception: insights from focal strokes affecting the perception of external and internal milieus.
Disentangling interoception: insights from focal strokes affecting the perception of external and internal milieus.
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DOI：
10.3389/fpsyg.2015.00503
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发表时间：
2015
影响因子：
3.8
通讯作者：
Ibanez A
中科院分区：
文献类型：
--
作者：
Couto B;Adolfi F;Sedeño L;Salles A;Canales-Johnson A;Alvarez-Abut P;Garcia-Cordero I;Pietto M;Bekinschtein T;Sigman M;Manes F;Ibanez A
内感受是对身体生理状况的即时感知。内感受的多模态来源可以分为两种不同的传入流：从核心结构产生的信号的内部通路（即，心脏、血管和支气管）和身体映射感觉的外部通路（即，化学感觉和疼痛）由周围空间引起。本研究探讨差异处理沿着这些流内岛叶皮层（IC）和他们的皮层下神经束连接额颞叶网络。两个罕见的患者表现出局灶性病变的IC（岛叶病变，IL）或其皮质下束（皮质下病变，SL）进行了测试。通过心跳检测（HBD）任务评估内部产生的内感受流，而外部触发的内感受流则通过味觉、嗅觉和疼痛识别任务进行评估。观察到差异模式。IC患者表现出受损的内部信号处理，而SL患者表现出外部感知缺陷。即使将每个患者与一组健康对照组和一组脑损伤患者进行比较，这种选择性缺陷仍然存在。这些结果表明存在可区分的内感受流。结果进行了讨论与神经解剖基板，涉及额岛颞网络的内感受性和认知的背景整合。
Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.
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影响因子：
2.5
作者：
Adolphs, R;Tranel, D;Damasio, AR
通讯作者：
Damasio, AR
DOI：
10.1073/pnas.98.4.2029
发表时间：
2001-02-13
影响因子：
11.1
作者：
Brannan, S;Liotti, M;Fox, PT
通讯作者：
Fox, PT
影响因子：
3.1
作者：
Ahmad, Shireen;De Oliveira, Gildasio S., Jr.;McCarthy, Robert J.
通讯作者：
McCarthy, Robert J.
影响因子：
9.2
作者：
Azanon, Elena;Soto-Faraco, Salvador
通讯作者：
Soto-Faraco, Salvador
影响因子：
2.6
作者：
Carlesimo, G. A.;Serra, L.;Caltagirone, C.
通讯作者：
Caltagirone, C.