Stable Regulation of Cell Cycle Events in Mycobacteria: Insights From Inherently Heterogeneous Bacterial Populations.
Stable Regulation of Cell Cycle Events in Mycobacteria: Insights From Inherently Heterogeneous Bacterial Populations.
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DOI：
10.3389/fmicb.2018.00514
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发表时间：
2018
影响因子：
5.2
通讯作者：
Aldridge BB
中科院分区：
文献类型：
--
作者：
Logsdon MM;Aldridge BB
模式菌如E. coli和B.枯草芽孢杆菌，严格调节细胞周期进程，以实现一致的细胞大小分布和复制动力学。这些模式细菌的许多标志性特征，包括细胞壁的横向延伸和对称生长和分裂，在分枝杆菌中不发生。相反，分枝杆菌生长的特征是不对称的极性生长和分裂。这种先天的不对称性造成了每次分裂时子细胞的出生大小和生长速度不相等，从而产生了表型异质的群体。虽然分枝杆菌的不对称生长模式导致出生大小的变化比通常在模型细菌种群中看到的更大，但细胞大小分布随时间推移是稳定的。在这里，我们回顾了分枝杆菌的生长，分裂和细胞周期进展的细胞机制，面对不对称性和固有的异质性。这些过程结合起来控制细胞大小。虽然耻垢分枝杆菌和牛分枝杆菌卡介苗（BCG）利用一种新的细胞大小控制模型，但它们与先前研究的细菌相似，因为DNA复制的启动是细胞分裂的关键检查点。我们比较了分枝杆菌和模式细菌中DNA复制起始的调节和细胞大小稳态的策略。最后，我们回顾了细胞组织和染色体分离与分枝杆菌生理学相关的重要性，并考虑如何在细菌多样性的广泛范围内应用新的框架。
Model bacteria, such as E. coli and B. subtilis, tightly regulate cell cycle progression to achieve consistent cell size distributions and replication dynamics. Many of the hallmark features of these model bacteria, including lateral cell wall elongation and symmetric growth and division, do not occur in mycobacteria. Instead, mycobacterial growth is characterized by asymmetric polar growth and division. This innate asymmetry creates unequal birth sizes and growth rates for daughter cells with each division, generating a phenotypically heterogeneous population. Although the asymmetric growth patterns of mycobacteria lead to a larger variation in birth size than typically seen in model bacterial populations, the cell size distribution is stable over time. Here, we review the cellular mechanisms of growth, division, and cell cycle progression in mycobacteria in the face of asymmetry and inherent heterogeneity. These processes coalesce to control cell size. Although Mycobacterium smegmatis and Mycobacterium bovis Bacillus Calmette-Guérin (BCG) utilize a novel model of cell size control, they are similar to previously studied bacteria in that initiation of DNA replication is a key checkpoint for cell division. We compare the regulation of DNA replication initiation and strategies used for cell size homeostasis in mycobacteria and model bacteria. Finally, we review the importance of cellular organization and chromosome segregation relating to the physiology of mycobacteria and consider how new frameworks could be applied across the wide spectrum of bacterial diversity.
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影响因子：
48
作者：
Godin, Michel;Delgado, Francisco Feijo;Son, Sungmin;Grover, William H.;Bryan, Andrea K.;Tzur, Amit;Jorgensen, Paul;Payer, Kris;Grossman, Alan D.;Kirschner, Marc W.;Manalis, Scott R.
通讯作者：
Manalis, Scott R.
影响因子：
3.6
作者：
Ginda, Katarzyna;Bezulska, Martyna;Jakimowicz, Dagmara
通讯作者：
Jakimowicz, Dagmara
影响因子：
3.4
作者：
Deforet, Maxime;van Ditmarsch, Dave;Xavier, Joao B.
通讯作者：
Xavier, Joao B.
DOI：
10.1038/nri.2017.69
发表时间：
2017-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Cadena AM;Fortune SM;Flynn JL
通讯作者：
Flynn JL
影响因子：
28.3
作者：
Eskandarian, Haig A.;Odermatt, Pascal D.;Fantner, Georg E.
通讯作者：
Fantner, Georg E.