Massive lateral transfer of genes encoding plant cell wall-degrading enzymes to the mycoparasitic fungus Trichoderma from its plant-associated hosts.
Massive lateral transfer of genes encoding plant cell wall-degrading enzymes to the mycoparasitic fungus Trichoderma from its plant-associated hosts.
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编码植物细胞壁降解酶的基因从植物相关宿主大规模横向转移到真菌寄生真菌木霉属
DOI：
10.1371/journal.pgen.1007322
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发表时间：
2018-04
期刊：
影响因子：
4.5
通讯作者：
Kubicek CP
中科院分区：
文献类型：
--
作者：
Druzhinina IS;Chenthamara K;Zhang J;Atanasova L;Yang D;Miao Y;Rahimi MJ;Grujic M;Cai F;Pourmehdi S;Salim KA;Pretzer C;Kopchinskiy AG;Henrissat B;Kuo A;Hundley H;Wang M;Aerts A;Salamov A;Lipzen A;LaButti K;Barry K;Grigoriev IV;Shen Q;Kubicek CP
与大多数其他真菌不同，木霉属霉菌是其他真菌的侵袭性寄生虫，也是植物生物量的有效分解者。虽然营养变化在下分泌物真菌中很常见，但没有像木霉中观察到的那样具有如此广泛的底物多功能性的例子。对23种下甲真菌(包括9种木霉菌)进行了系统发育分析。和相关的Ecovopsis weberi)揭示了木霉属是从以真菌或节肢动物为食的有限分解纤维的祖先进化而来的。基于基因树/种树协调的木霉编码植物细胞壁降解碳水化合物活性酶和辅助蛋白的基因(pcwdCAZome，122个基因家族)的进化分析表明，该属的形成伴随着前所未有的横向基因转移(LGT)。在木霉PCwdCAZome中，近一半(41%)的基因是通过LGT从属于不同子囊菌门的植物相关丝状真菌中获得的，而没有从其他潜在的供体那里观察到LGT。除了能够捕食不相关的真菌(如担子菌门)外，我们还发现木霉菌能够在广泛的子囊菌门上寄生，包括现有的LGT供体。这一现象在E.weberi中没有观察到，在其他真菌寄生的下分泌物真菌中也很少见。因此，我们的研究表明，LGT与木霉寄生分类学上相关的真菌的能力有关(严格意义上的附生)。这可能主要允许真菌营养木霉真菌进化为植物生物量的分解者。
Unlike most other fungi, molds of the genus Trichoderma (Hypocreales, Ascomycota) are aggressive parasites of other fungi and efficient decomposers of plant biomass. Although nutritional shifts are common among hypocrealean fungi, there are no examples of such broad substrate versatility as that observed in Trichoderma. A phylogenomic analysis of 23 hypocrealean fungi (including nine Trichoderma spp. and the related Escovopsis weberi) revealed that the genus Trichoderma has evolved from an ancestor with limited cellulolytic capability that fed on either fungi or arthropods. The evolutionary analysis of Trichoderma genes encoding plant cell wall-degrading carbohydrate-active enzymes and auxiliary proteins (pcwdCAZome, 122 gene families) based on a gene tree / species tree reconciliation demonstrated that the formation of the genus was accompanied by an unprecedented extent of lateral gene transfer (LGT). Nearly one-half of the genes in Trichoderma pcwdCAZome (41%) were obtained via LGT from plant-associated filamentous fungi belonging to different classes of Ascomycota, while no LGT was observed from other potential donors. In addition to the ability to feed on unrelated fungi (such as Basidiomycota), we also showed that Trichoderma is capable of endoparasitism on a broad range of Ascomycota, including extant LGT donors. This phenomenon was not observed in E. weberi and rarely in other mycoparasitic hypocrealean fungi. Thus, our study suggests that LGT is linked to the ability of Trichoderma to parasitize taxonomically related fungi (up to adelphoparasitism in strict sense). This may have allowed primarily mycotrophic Trichoderma fungi to evolve into decomposers of plant biomass.
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影响因子：
10.7
作者：
Castresana, J
通讯作者：
Castresana, J
影响因子：
5.4
作者：
Bissett J;Gams W;Jaklitsch W;Samuels GJ
通讯作者：
Samuels GJ
影响因子：
2.8
作者：
Chaverri P;Branco-Rocha F;Jaklitsch W;Gazis R;Degenkolb T;Samuels GJ
通讯作者：
Samuels GJ
影响因子：
3.7
作者：
Druzhinina IS;Komoń-Zelazowska M;Atanasova L;Seidl V;Kubicek CP
通讯作者：
Kubicek CP
影响因子：
4.5
作者：
Coleman JJ;Rounsley SD;Rodriguez-Carres M;Kuo A;Wasmann CC;Grimwood J;Schmutz J;Taga M;White GJ;Zhou S;Schwartz DC;Freitag M;Ma LJ;Danchin EG;Henrissat B;Coutinho PM;Nelson DR;Straney D;Napoli CA;Barker BM;Gribskov M;Rep M;Kroken S;Molnár I;Rensing C;Kennell JC;Zamora J;Farman ML;Selker EU;Salamov A;Shapiro H;Pangilinan J;Lindquist E;Lamers C;Grigoriev IV;Geiser DM;Covert SF;Temporini E;Vanetten HD
通讯作者：
Vanetten HD