Cilia in the CNS: the quiet organelle claims center stage.
Cilia in the CNS: the quiet organelle claims center stage.
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CNS中的纤毛：安静的细胞器声称中心舞台。
DOI：
10.1016/j.neuron.2011.03.002
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发表时间：
2011-03-24
期刊：
影响因子：
16.2
通讯作者：
Grove EA
中科院分区：
文献类型：
--
作者：
Louvi A;Grove EA
The primary cilium is a cellular organelle that is almost ubiquitous in eukaryotes, yet its functions in vertebrates have been slow to emerge. The last fifteen years have been marked by accelerating insight into the biology of primary cilia, arising from the synergy of three major lines of research. These research programs describe a specialized mode of protein trafficking in cilia, reveal that genetic disruptions of primary cilia cause complex human disease syndromes, and establish that Sonic hedgehog (Shh) signal transduction requires the primary cilium. New lines of research have branched off to investigate the role of primary cilia in neuronal signaling, adult neurogenesis, and brain tumor formation. We review a fast expanding literature to determine what we now know about the primary cilium in the developing and adult CNS, and what new directions should lead to further clarity.
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影响因子：
64.8
作者：
Barr, MM;Sternberg, PW
通讯作者：
Sternberg, PW
DOI：
10.1016/s0022-5320(61)80019-1
发表时间：
1961-01-01
期刊：
JOURNAL OF ULTRASTRUCTURE RESEARCH
影响因子：
--
作者：
BARNES, BG
通讯作者：
BARNES, BG
影响因子：
4.6
作者：
Banizs, B;Pike, MM;Yoder, BK
通讯作者：
Yoder, BK
DOI：
10.1016/j.cub.2009.07.034
发表时间：
2009-09-15
期刊：
Current biology : CB
影响因子：
--
作者：
Anderson CT;Stearns T
通讯作者：
Stearns T
影响因子：
64.5
作者：
Charron, F;Stein, E;Tessier-Lavigne, M
通讯作者：
Tessier-Lavigne, M