The Evolution of Gene Expression in cis and trans.

The Evolution of Gene Expression in cis and trans.
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DOI:
10.1016/j.tig.2018.03.007
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发表时间:
2018-07
期刊:
Trends in genetics : TIG
影响因子:
--
通讯作者:
Nuzhdin SV
Nuzhdin SV
中科院分区:
其他
文献类型:
--
作者:
Signor SA;Nuzhdin SV

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个体、种群和物种之间的基因表达存在丰富的变异。物种内部和物种之间基因调控和表达的进化被认为经常有助于适应。然而,大量证据表明,影响基因表达变异的主要进化力量是稳定选择。在这里,我们回顾最近的研究结果的特点发生在顺式(通过连锁多态性)或反式(通过其他基因的扩散产品)和他们的贡献,适应和响应环境的基因表达的演变。我们回顾了在转录和翻译水平上缓冲基因表达变化的证据,以及这种缓冲的可能机制。最后,我们总结了尚未解决的问题,基因调控的进化。
There is abundant variation in gene expression between individuals, populations, and species. The evolution of gene regulation and expression within and between species is thought to frequently contribute to adaptation. Yet considerable evidence suggests that the primary evolutionary force acting on variation in gene expression is stabilizing selection. We review here the results of recent studies characterizing the evolution of gene expression occurring in cis (via linked polymorphisms) or in trans (through diffusible products of other genes) and their contribution to adaptation and response to the environment. We review the evidence for buffering of variation in gene expression both at the level of transcription and translation, and the possible mechanisms for this buffering. Lastly, we summarize unresolved questions about the evolution of gene regulation.
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