Infection-mimicking materials to program dendritic cells in situ.
Infection-mimicking materials to program dendritic cells in situ.
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作者：
癌症疫苗通常依赖于在实验室中对细胞进行繁琐且昂贵的操作，随后的细胞移植导致淋巴结归巢不良和疗效有限。我们建议，模仿细菌感染关键方面的材料可以用于直接控制体内免疫细胞的运输和激活。它表明，聚合物可以被设计为首先释放细胞因子来招募和容纳宿主树突状细胞（DC），随后呈递癌抗原和危险信号来激活驻留的DC并显着增强它们归巢到淋巴结。这些材料产生了特异性和保护性抗肿瘤免疫，因为在25天内死于癌症的动物中实现了90%的存活率。这些材料显示出作为癌症疫苗的前景，并且更广泛地表明聚合物可以被设计用于编程和控制体内各种细胞类型的运输。
Cancer vaccines typically depend on cumbersome and expensive manipulation of cells in the laboratory, and subsequent cell transplantation leads to poor lymph node homing and limited efficacy. We propose that materials mimicking key aspects of bacterial infection may instead be used to directly control immune cell trafficking and activation in the body. It is demonstrated that polymers can be designed to first release a cytokine to recruit and house host dendritic cells (DCs), and subsequently present cancer antigens and danger signals to activate the resident DCs and dramatically enhance their homing to lymph nodes. Specific and protective anti-tumor immunity was generated with these materials, as 90% survival was achieved in animals that otherwise die from cancer within 25 days. These materials show promise as cancer vaccines, and more broadly suggest that polymers may be designed to program and control the trafficking of a variety of cell types in the body.
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DOI：
10.1111/j.1749-6632.2002.tb03056.x
发表时间：
2002-01-01
期刊：
REPARATIVE MEDICINE: GROWING TISSUES AND ORGANS
影响因子：
--
作者：
Griffith, LG
通讯作者：
Griffith, LG
DOI：
10.1111/j.1552-6909.2008.00247.x
发表时间：
2008-05-01
影响因子：
1.8
作者：
Fischer, Mary A.
通讯作者：
Fischer, Mary A.
影响因子：
6.5
作者：
Okamoto, T;Irie, RF;Hoon, DSB
通讯作者：
Hoon, DSB
影响因子：
3.9
作者：
Rosenberg, SA;White, DE
通讯作者：
White, DE
影响因子：
10.8
作者：
Sheridan, MH;Shea, LD;Mooney, DJ
通讯作者：
Mooney, DJ