Alcohol-induced brain growth restrictions (microencephaly) were not affected by concurrent exposure to cocaine during the brain growth spurt.
Alcohol-induced brain growth restrictions (microencephaly) were not affected by concurrent exposure to cocaine during the brain growth spurt.
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酒精引起的大脑生长受限（小脑畸形）不受大脑生长突增期间同时接触可卡因的影响。
DOI：
10.1002/tera.1420500310
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
West,JR
中科院分区：
文献类型：
--
作者：
Chen,WJ;Andersen,KH;West,JR
吸毒者普遍同时使用酒精和可卡因，这引起了人们对可能增加胎儿损害风险的担忧。本研究的目的是使用动物模型系统评估酒精和可卡因对致死率、躯体生长和大脑生长的相互作用影响。斯普拉格-道利大鼠幼崽被用作受试者。它们被随机分配到 9 个人工饲养组中的一组，这些组的可卡因（0、40 或 60 毫克/千克）和酒精（0、3.3 或 4.5 克/千克）的联合治疗各不相同。所有人工饲养的幼崽在大脑生长突增期（出生后第 4-9 天）的大部分时间里每天都接受可卡因和酒精治疗。另外一组由天然水坝饲养的哺乳对照动物也被纳入其中，以控制人工饲养。结果总结如下：（1）与非可卡因治疗组相比，可卡因治疗组的药物致死率较高，并且同时服用高剂量酒精和可卡因显着增加死亡率。 (2)采用人工饲养技术，体重方面的体细胞生长不受酒精、可卡因或这两种药物的组合的影响。 (3) 在大脑快速生长期接触酒精会显着降低整个大脑的重量，以及前脑、小脑和脑干的重量。 (4) 与酒精相比，可卡因在产后早期并未对脑重量测量产生有害影响。 (5)在脑生长突增期间同时接触酒精和可卡因对引起脑生长限制不存在拮抗或协同作用。讨论了可卡乙烯在介导观察到的致死率中的潜在参与。 © 1994 Wiley-Liss, Inc.
The prevalence of concomitant use of alcohol and cocaine among drug abusers has raised concern about the possible increased risk of fetal damage. The aim of this study was to assess the interactive effects of alcohol and cocaine on lethality, somatic growth, and brain growth using an animal model system. Sprague‐Dawley rat pups were used as subjects. They were randomly assigned to 1 of the 9 artificially reared groups which varied with respect to the combination treatments of cocaine (0, 40, or 60 mg/kg) and alcohol (0, 3.3, or 4.5 g/kg). All artificially reared pups were given daily cocaine and alcohol treatments during a major part of the brain growth spurt period (postnatal days 4–9). An additional group of suckled control animals raised by their natural dams was included to control for artificial rearing. The results are summarized as follows: (1) Drug‐induced lethality was higher in cocaine‐treated groups when compared with non‐cocaine‐treated groups, and the concurrent administration of high doses of alcohol and cocaine significantly increased the mortality rate. (2) Somatic growth, in terms of body weight, was not affected by alcohol, cocaine, or the combination of both drugs using the artificial rearing technique. (3) Alcohol exposure during this brain growth spurt period significantly reduced whole brain weight, as well as forebrain, cerebellum, and brain stem weights. (4) In contrast to alcohol, cocaine failed to exert a detrimental effect on brain weight measures during this early postnatal period. (5) There were no antagonistic or synergistic effects in inducing brain growth restrictions by concurrent exposure to alcohol and cocaine during the brain growth spurt. The potential involvement of cocaethylene in mediating the observed lethality is discussed. © 1994 Wiley‐Liss, Inc.
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产后早期酒精暴露后神经元的差异性损失。
DOI：
10.1002/tera.1420400205
发表时间：
1989
期刊：
Teratology
影响因子：
--
作者：
Pierce,DR;Goodlett,CR;West,JR
通讯作者：
West,JR
母亲在怀孕期间使用可卡因后的影响之谜：是否存在可协调的差异？
影响因子：
2.9
作者：
Hutchings,DE
通讯作者：
Hutchings,DE
影响因子：
4.2
作者：
GRANT, BF;HARFORD, TC
通讯作者：
HARFORD, TC
乙醇/可卡因相互作用：可卡因和可卡乙烯血浆浓度及其与主观和心血管效应的关系。
影响因子：
6.1
作者：
Perez-Reyes,M;Jeffcoat,AR
通讯作者：
Jeffcoat,AR
大脑快速生长期间的可卡因暴露：新生儿存活、体细胞生长和大脑发育的研究。
影响因子：
2.9
作者：
Chen,WJ;Andersen,KH;West,JR
通讯作者：
West,JR