Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment.
Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment.
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视网膜毛细血管丛血管密度降低和神经节细胞复合体变薄与认知障碍相关
DOI：
10.3389/fnagi.2022.872466
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
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作者：
利用光学相干断层扫描血管造影（OCTA）确定视网膜毛细血管丛（RCP）和神经节细胞复合体（GCC）与认知功能障碍的关系。一项基于社区的横断面研究，利用了2019年8月至2020年1月在冀东眼科队列研究中招募的参与者的数据。我们使用OCTA评估RCP和GCC厚度中的血管密度，并使用蒙特利尔认知评估（莫卡）进行认知测试。本研究中的认知障碍定义为莫卡评分< 24。在调整混杂因素后，我们使用多变量分析来评估RCP和GCC与认知功能障碍的相关性。这项研究分析了1555名参与者。参与者的平均年龄为52.3（8.4）岁，861（55.4%）为女性。在268名（17.2%）参与者中观察到认知障碍。在有认知功能障碍的深RCP中，动脉旁血管密度的校正比值比（OR）和95%置信区间（95%CI）为1.20（1.03-1.39）。对于认知功能障碍的中心凹无血管区周围的血管面积和长度密度，OR和95%CI分别为1.23（1.07-1.41）和1.30（1.13-1.49）。对于伴有认知功能障碍的上级GCC的厚度，OR和95% CI为1.16（1.01-1.32）。RCP中较低的血管密度和较薄的GCC与认知障碍相关。我们的研究结果表明，RCP和GCC的改变可以在评估认知功能时提供进一步的证据，甚至可能是检测认知障碍的潜在有用的生物标志物。
To determine the association of the retinal capillary plexus (RCP) and ganglion cell complex (GCC) with cognitive impairment using optical coherence tomography angiography (OCTA). A cross-sectional, community-based study utilizing data from the participants enrolled between August 2019 and January 2020 in the Jidong Eye Cohort Study. We assessed the vessel density in RCP and GCC thickness using OCTA, and cognitive testing using the Montreal Cognitive Assessment (MoCA). Cognitive impairment in this study was defined as MoCA score < 24. We used multivariable analysis to evaluate the association of RCP and GCC with cognitive impairment after adjusting for confounders. This study analyzed 1555 participants. The mean age of participants was 52.3 (8.4) years, and 861 (55.4%) were women. Cognitive impairment was observed in 268 (17.2%) participants. The adjusted odds ratio (OR) with 95% confidence interval (95% CI) for parafovea vessel density in the deep RCP with cognitive impairment was 1.20 (1.03–1.39). For vessel area and length density surrounding foveal avascular zone with cognitive impairment, the ORs with 95% CIs were 1.23 (1.07–1.41) and 1.30 (1.13–1.49), respectively. For thickness in the superior GCC with cognitive impairment, the OR with 95% CI was 1.16 (1.01–1.32). Lower vessel density in the RCP and thinner GCC were associated with cognitive impairment. Our results suggest that alterations in the RCP and GCC could provide further evidence when assessing the cognitive function and may even be potentially useful biomarkers in the detection of cognitive impairment.
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DOI：
10.1038/s41582-018-0079-7
发表时间：
2018-11
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Hampel H;O'Bryant SE;Molinuevo JL;Zetterberg H;Masters CL;Lista S;Kiddle SJ;Batrla R;Blennow K
通讯作者：
Blennow K
影响因子：
3.4
作者：
Kraus MF;Potsaid B;Mayer MA;Bock R;Baumann B;Liu JJ;Hornegger J;Fujimoto JG
通讯作者：
Fujimoto JG
影响因子：
14
作者：
Ding, Ding;Zhao, Qianhua;Hong, Zhen
通讯作者：
Hong, Zhen
影响因子：
9.9
作者：
Koepsell, Thomas D.;Monsell, Sarah E.
通讯作者：
Monsell, Sarah E.
DOI：
10.1097/wno.0000000000000580
发表时间：
2018-09
期刊：
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
影响因子：
--
作者：
Jiang H;Wei Y;Shi Y;Wright CB;Sun X;Gregori G;Zheng F;Vanner EA;Lam BL;Rundek T;Wang J
通讯作者：
Wang J