Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis.
Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis.
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DOI：
10.1016/j.freeradbiomed.2009.06.020
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发表时间：
2009-09-15
影响因子：
7.4
通讯作者：
Yazlovitskaya, Eugenia
中科院分区：
文献类型：
--
作者：
Thotala, Dinesh;Chetyrkin, Sergei;Hudson, Billy;Hallahan, Dennis;Voziyan, Paul;Yazlovitskaya, Eugenia
关键词：
活性氧（ROS）和活性羰基（RCS）是电离辐射（IR）照射下生物组织损伤的主要原因。现有的保护正常组织免受IR有害影响的策略遭受几个缺点，包括高毒副作用、不利的给药途径或低功效。这些缺点强调了对将联合收割机有效性与安全性和易用性相结合的辐射防护治疗的需要。在本文中，我们证明了吡哆胺，一个非常有利的安全性的ROS和RCS清除剂，可以抑制IR诱导的胃肠道内皮细胞凋亡的细胞培养和动物模型。吡哆胺在防止辐射诱导的细胞凋亡方面比氨磷汀更有效，氨磷汀是一种合成的硫醇化合物，也是FDA批准的唯一的辐射保护剂。我们认为，PM有潜力作为一种有效和安全的辐射防护剂。
Reactive oxygen species (ROS) and reactive carbonyl species (RCS) are the major cause of biological tissue damage during the exposure to ionizing radiation (IR). The existing strategies to protect normal tissues from detrimental effects of IR suffer from several shortcomings including high toxic side effects, unfavorable administration routs or low efficacy. These shortcomings emphasize a need for radioprotective treatments that combine effectiveness with safety and ease of use. In this paper, we demonstrate that pyridoxamine, a ROS and RCS scavenger with a very favorable safety profile, can inhibit IR-induced gastrointestinal endothelial apoptosis in cell culture and in animal model. Pyridoxamine was more effective at protecting from radiation-induced apoptosis compared to Amifostine, a synthetic thiol compound and the only FDA approved radioprotector. We suggest that PM has a potential as an effective and safe radioprotective agent.
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