Psychiatric symptom burden in older people living with HIV with and without cognitive impairment: the UCSF HIV over 60 cohort study.
Psychiatric symptom burden in older people living with HIV with and without cognitive impairment: the UCSF HIV over 60 cohort study.
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DOI：
10.1080/09540121.2017.1281877
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发表时间：
2017-09
期刊：
影响因子：
1.7
通讯作者：
Valcour V
中科院分区：
文献类型：
--
作者：
Milanini B;Catella S;Perkovich B;Esmaeili-Firidouni P;Wendelken L;Paul R;Greene M;Ketelle R;Valcour V
精神合并症在艾滋病毒感染者 (PLWH) 中很常见，会对生活满意度、治疗依从性和疾病进展产生不利影响。很少有数据可以说明老年 PLWH 的精神症状负担，而老年 PLWH 的人口数量在美国迅速增长。我们进行了一项横断面分析，以了解 60 岁以上 PLWH 的症状负担与认知障碍的相关程度。参与者完成了标准化的神经心理学电池组，并使用弗拉斯卡蒂标准进行了认知诊断。我们使用老年抑郁量表（GDS）和代理知情神经精神问卷调查表（NPI-Q）来捕获精神症状负担。被诊断患有 HIV 相关神经认知障碍的患者 (HAND，n = 39) 在年龄（每组中位数 = 67 岁，p = 0.696）、教育程度（平均值 = 16 岁 vs. 17 岁，p = 0.096）、CD4+ T 淋巴细胞计数（平均值 = 520 vs. 579，p = 0.096）方面与未患 HAND 的患者 (n = 35) 相似。 0.240）、HIV 持续时间（每组中位数 = 21 年，p = 0.911）和性别（HAND 中 92% 为男性，非 HAND 中为 97%，p = 0.617）。我们的研究结果表明，HAND 组和非 HAND 组在 NPI-Q（项目和聚类）和 GDS 评分上有相似之处。然而，与健康老年对照组相比，艾滋病毒感染者的总体症状负担更大（n = 236，p < 0.05），更频繁地出现激动、抑郁、焦虑、冷漠、易怒和夜间行为障碍（p < 0.05）。我们的研究结果表明，老年 HIV 参与者的 HAND 状态在精神合并症方面没有差异；但证实了这一老年艾滋病毒感染人群存在巨大的神经行为负担。
Psychiatric comorbidities are common in people living with HIV (PLWH) and adversely affect life satisfaction, treatment adherence and disease progression. There are few data to inform the burden of psychiatric symptoms in older PLWH, a rapidly growing demographic in the U.S. We performed a cross-sectional analysis to understand the degree to which symptom burden was associated with cognitive disorders in PLWH over age 60. Participants completed a standardized neuropsychological battery and were assigned cognitive diagnoses using Frascati criteria. We captured psychiatric symptom burden using the Geriatric Depression Scale (GDS) and proxy-informed Neuropsychiatric Inventory-Questionnaire (NPI-Q). Those diagnosed with HIV-associated Neurocognitive Disorders (HAND, n = 39) were similar to those without HAND (n = 35) by age (median = 67 years for each group, p = 0.696), education (mean = 16 years vs. 17 years, p = 0.096), CD4+ T-lymphocyte counts (mean = 520 vs. 579, p = 0.240), duration of HIV (median = 21 years for each group, p = 0.911) and sex (92% male in HAND vs. 97% in non-HAND, p = 0.617). Our findings showed similarities in HAND and non-HAND groups on both NPI-Q (items and clusters) and GDS scores. However, there was a greater overall symptom burden in HIV compared to healthy elder controls (n = 236, p < 0.05), with more frequent agitation, depression, anxiety, apathy, irritability and nighttime behavior disturbances (p < 0.05). Our findings demonstrate no differences in psychiatric comorbidity by HAND status in older HIV participants; but confirm a substantial neurobehavioral burden in this older HIV-infected population.
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DOI：
10.1080/13803390590935444
发表时间：
2006-04-01
影响因子：
2.2
作者：
Castellon, SA;Hardy, DJ;Moore, L
通讯作者：
Moore, L
影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor
影响因子：
7
作者：
Cummings, Jeffrey L.;Ihl, Ralf;Tribanek, Michael
通讯作者：
Tribanek, Michael
影响因子：
12.7
作者：
Gerst-Emerson, Kerstin;Jayawardhana, Jayani
通讯作者：
Jayawardhana, Jayani
影响因子：
4.9
作者：
Haddow, Lewis J.;Dudau, Cristina;Jaeger, H. Rolf
通讯作者：
Jaeger, H. Rolf