A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus.
A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus.
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DOI：
10.1111/j.1532-5415.2011.03819.x
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发表时间：
2012-03
影响因子：
6.3
通讯作者：
Hall WJ
中科院分区：
文献类型：
--
作者：
Shah K;Hilton TN;Myers L;Pinto JF;Luque AE;Hall WJ
评估社区hiv感染老年人（HOA）身体组成与身体虚弱之间的关系。横截面。纽约州罗彻斯特的学术医院传染病诊所社区居住的艾滋病毒感染成人bbbb50岁。通过物理性能测试（PPT）、分级跑步机测试、膝关节力量、步态速度、平衡和功能状态问卷（FSQ）评估主观和客观功能状态指标。采用双能x线吸收仪（DXA）和磁共振成像（MRI）评估体成分。我们研究了40名接受抗逆转录病毒治疗的HOA（平均年龄58岁，BMI 29， CD4 569细胞/ml，自HIV诊断以来持续时间17年；28%的女性和57%的高加索人），他们能够在没有辅助装置的情况下行走。60%（25/40）的受试者符合我们身体虚弱的标准标准。体弱（FR）和非体弱（NF）受试者在年龄、性别、CD4计数和病毒载量方面具有可比性。与NF HOA相比，FR HOA在PPT、峰值有氧能力（vo2峰值）、FSQ、步行速度、平衡和肌肉质量方面表现出损伤。重要的是，FR HOA有更高的身体质量指数（BMI），脂肪量和躯干脂肪与脂肪营养不良。此外，调整协变量后，PPT评分与躯干脂肪（r= - 0.34, p=0.045）和肌间脂肪（IMF）与总脂肪比（r= - 60, p=0.02）呈负相关。HOA代表了一个新兴的老年人群体，他们经常在比一般老年人年轻得多的年龄经历虚弱。中心性肥胖和脂肪再分配是社区居民HOA中虚弱的重要预测因素。这些发现表明，HOA患者的身体虚弱可能与生活方式干预有关，尤其是运动和饮食治疗。
To evaluate the relationships between body composition and physical frailty in community-dwelling HIV-infected older adults (HOA). Cross-sectional. Academic hospital-based infectious disease clinic in Rochester NY Community-dwelling HIV-infected adults >50 years of age. Subjective and objective measures of functional status were evaluated by using the Physical Performance Test (PPT), graded treadmill test, knee strength, gait speed, balance and Functional Status Questionnaires (FSQ). Body composition was evaluated by using Dual Energy X-ray Absorptiometry (DXA) and Magnetic Resonance Imaging (MRI). We studied 40 HOA on antiretroviral therapy (with mean: age 58 years, BMI 29, CD4 569 cells/ml, duration since HIV diagnosis 17 years; 28% female and 57% Caucasian) who were able to ambulate without assistive devices. Sixty percent (25/40) of the subjects met our standard criteria for physical frailty. Both frail (FR) and non-frail (NF) subjects were comparable in age, gender, CD4 count and viral load. Compared to NF HOA, FR HOA showed impairments in PPT, peak aerobic power (VO2peak), FSQ, walking speed, balance and muscle quality. Importantly, FR HOA had greater body mass index (BMI), fat mass and truncal fat with lipodystrophy. Moreover, PPT score was inversely related to both trunk fat (r=−0.34; p=0.045) and intermuscular fat (IMF) to total fat ratio (r=−60; p=0.02) after adjusting for covariates. HOA represent an emerging cohort of older adults who frequently experience frailty at a much younger age compared to the general older population. Central obesity and fat redistribution are important predictors of frailty among community-dwelling HOA. These findings suggest that physical frailty in HOA may be amenable to lifestyle interventions, especially exercise and diet therapy.
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影响因子：
3.7
作者：
Crum-Cianflone N;Roediger MP;Eberly L;Headd M;Marconi V;Ganesan A;Weintrob A;Barthel RV;Fraser S;Agan BK;Infectious Disease Clinical Research Program HIV Working Group
通讯作者：
Infectious Disease Clinical Research Program HIV Working Group
DOI：
10.1093/gerona/55.6.m350
发表时间：
2000-06-01
影响因子：
5.1
作者：
Brown, M;Sinacore, DR;Kohrt, WM
通讯作者：
Kohrt, WM
DOI：
10.1097/00126334-200306012-00003
发表时间：
2003-06-01
影响因子：
3.6
作者：
Mack, KA;Ory, MG
通讯作者：
Ory, MG
DOI：
10.1093/gerona/56.3.m158
发表时间：
2001-03-01
影响因子：
5.1
作者：
Newman, AB;Gottdiener, JS;Fried, LP
通讯作者：
Fried, LP
DOI：
10.1038/oby.2004.111
发表时间：
2004-06-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Villareal, DT;Banks, M;Klein, S
通讯作者：
Klein, S