Increasing rates of obesity among HIV-infected persons during the HIV epidemic.
Increasing rates of obesity among HIV-infected persons during the HIV epidemic.
复制标题
DOI：
10.1371/journal.pone.0010106
复制
发表时间：
2010-04-09
期刊：
影响因子：
3.7
通讯作者：
Infectious Disease Clinical Research Program HIV Working Group
中科院分区：
文献类型：
--
作者：
Crum-Cianflone N;Roediger MP;Eberly L;Headd M;Marconi V;Ganesan A;Weintrob A;Barthel RV;Fraser S;Agan BK;Infectious Disease Clinical Research Program HIV Working Group
与人类免疫缺陷病毒（艾滋病毒）感染者超重/肥胖有关的流行率和因素尚不清楚。我们评估了来自美国军事HIV自然史研究（1985-2004）的前瞻性数据，包括早期诊断的患者。统计方法包括多元线性回归和纵向线性混合效应模型。在1682名患者中，2%的人在诊断时体重不足，37%的人超重，9%的人肥胖。诊断时较高的体重指数（BMI）的多变量预测因素包括最近一年的HIV诊断、年龄较大、非裔美国人种族和早期HIV分期（所有p<0.05）。大多数患者（62%）在HIV感染期间体重增加。与HIV感染期间BMI增加更大相关的多变量因素包括最近一年的诊断，诊断时BMI较低，CD 4计数较高，HIV RNA水平较低，缺乏AIDS诊断和HIV持续时间较长（所有p<0.05）。核苷类药物与体重增加较少相关;其他药物类别在HAART时代对体重变化没有显著影响。艾滋病毒感染患者在诊断时和艾滋病毒感染期间越来越超重/肥胖。体重增加似乎反映了健康状况的改善，并反映了一般人群的趋势。体重管理计划可能是艾滋病毒护理的重要组成部分。
The prevalence and factors associated with overweight/obesity among human immunodeficiency virus (HIV)-infected persons are unknown. We evaluated prospective data from a U.S. Military HIV Natural History Study (1985–2004) consisting of early diagnosed patients. Statistics included multivariate linear regression and longitudinal linear mixed effects models. Of 1682 patients, 2% were underweight, 37% were overweight, and 9% were obese at HIV diagnosis. Multivariate predictors of a higher body mass index (BMI) at diagnosis included more recent year of HIV diagnosis, older age, African American race, and earlier HIV stage (all p<0.05). The majority of patients (62%) gained weight during HIV infection. Multivariate factors associated with a greater increase in BMI during HIV infection included more recent year of diagnosis, lower BMI at diagnosis, higher CD4 count, lower HIV RNA level, lack of AIDS diagnosis, and longer HIV duration (all p<0.05). Nucleoside agents were associated with less weight gain; other drug classes had no significant impact on weight change in the HAART era. HIV-infected patients are increasingly overweight/obese at diagnosis and during HIV infection. Weight gain appears to reflect improved health status and mirror trends in the general population. Weight management programs may be important components of HIV care.
登录
查看更多内容
影响因子：
11.8
作者：
Campa, A;Yang, ZF;Baum, MK
通讯作者：
Baum, MK
DOI：
10.1016/s0140-6736(08)61113-7
发表时间：
2008-07-26
期刊：
Lancet (London, England)
影响因子：
--
作者：
Antiretroviral Therapy Cohort Collaboration
通讯作者：
Antiretroviral Therapy Cohort Collaboration
影响因子：
120.7
作者：
Fontaine, KR;Redden, DT;Allison, DB
通讯作者：
Allison, DB
影响因子：
4.9
作者：
Crum-Cianflone N;Tejidor R;Medina S;Barahona I;Ganesan A
通讯作者：
Ganesan A
影响因子：
4.9
作者：
Ferrando, SJ;Rabkin, JG;McElhiney, M
通讯作者：
McElhiney, M