Abstinence-dependent transfer of lithium chloride-induced sucrose aversion to a sucrose-paired cue in rats.
Abstinence-dependent transfer of lithium chloride-induced sucrose aversion to a sucrose-paired cue in rats.
复制标题
DOI：
10.1007/s00213-009-1755-5
复制
发表时间：
2010-03
影响因子：
3.4
通讯作者：
Grimm, Jeffrey W.
中科院分区：
文献类型：
--
作者：
Harkness, John H.;Webb, Sierra;Grimm, Jeffrey W.
对药物或蔗糖配对线索的反应比强迫禁欲（渴望的孵化）更强。如果线索的激励价值取决于主要奖励的激励价值，那么贬低主要奖励应该会降低线索的反应性。我们调查了条件性味觉厌恶（CTA）是否会转移到蔗糖配对线索后1或30天的强制禁欲和CTA后1天的强制禁欲是否会影响孵化的渴望。大鼠自我给药10%蔗糖与音调+光提示配对，持续10天。在1天（实验1）或30天（实验2）强制禁欲后，大鼠接受两个家庭笼配对的蔗糖与LiCl（65 mg/kg，IP）以产生CTA或生理盐水作为对照。两天后，老鼠只对暗示做出反应。第二天，在相同的操作性调节室中评估蔗糖消耗。实验1大鼠在1个月后再次测试以确定CTA是否会影响渴望的孵化。实验1：CTA后1天的强制禁欲没有减弱线索反应时，立即测试CTA后，也没有处理影响孵化的渴望或孵化的蔗糖消耗。实验2：强制禁欲1个月后的CTA导致线索反应性显著降低。蔗糖的激励值和蔗糖的条件代表性增加了一段时间的强制禁欲。这种潜伏似乎有助于将对主要奖励的厌恶转移到条件线索上。
Responding for a drug- or sucrose-paired cue increases over forced abstinence (incubation of craving). If the incentive value of a cue depends on the incentive value of the primary reward, devaluing the primary reward should reduce cue reactivity. We investigated whether conditioned taste aversion (CTA) to sucrose would transfer to a sucrose-paired cue after 1 or 30 days of forced abstinence and whether CTA after 1 day of forced abstinence would affect incubation of craving. Rats self-administered 10% sucrose paired with a tone + light cue for 10 days. After 1 (Exp.1) or 30 (Exp.2) days of forced abstinence, rats received two home-cage pairings of sucrose with either LiCl (65 mg/kg, IP) to produce CTA or saline as a control. Two days later, rats responded for the cue alone. The following day, sucrose consumption was assessed in the same operant conditioning chamber. Exp.1 rats were tested again 1 month later to determine if CTA would affect incubation of craving. Exp.1: CTA after 1 day of forced abstinence did not attenuate cue reactivity when tested immediately after CTA, nor did the treatment affect incubation of craving or incubation of sucrose consumption. Exp.2: CTA after 1 month of forced abstinence resulted in a significant reduction in cue reactivity. The incentive values of sucrose and the conditioned representation of sucrose increase over an extended period of forced abstinence. This incubation appears to facilitate the transfer of an aversion to the primary reward to the conditioned cue.
登录
查看更多内容
影响因子：
3.4
作者：
Fenu, S;Di Chiara, G
通讯作者：
Di Chiara, G
中央杏仁核细胞外信号调节激酶信号通路对于阿片类药物渴望的孵化至关重要
DOI：
10.1523/jneurosci.3027-08.2008
发表时间：
2008-12-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Li YQ;Li FQ;Wang XY;Wu P;Zhao M;Xu CM;Shaham Y;Lu L
通讯作者：
Lu L
影响因子：
1.8
作者：
Holland, PC
通讯作者：
Holland, PC
影响因子：
2.3
作者：
Nava, Felice;Caldiroli, Emanuela;Lucchini, Alfio
通讯作者：
Lucchini, Alfio
影响因子：
1.6
作者：
Grimm JW;Osincup D;Wells B;Manaois M;Fyall A;Buse C;Harkness JH
通讯作者：
Harkness JH