Regulation of IFN-γ by IL-13 dictates susceptibility to secondary postinfluenza MRSA pneumonia.
Regulation of IFN-γ by IL-13 dictates susceptibility to secondary postinfluenza MRSA pneumonia.
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DOI：
10.1002/eji.201444582
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发表时间：
2014-11
影响因子：
5.4
通讯作者：
Harmsen, Allen G.
中科院分区：
文献类型：
--
作者：
Rynda-Apple, Agnieszka;Harmsen, Ann;Erickson, Anfin S.;Larson, Kyle;Morton, Rachelle V.;Richert, Laura E.;Harmsen, Allen G.
流感感染后第7天小鼠的超级感染至少部分通过IFN-γ信号传导增加的下游效应加剧了细菌性肺炎。本研究表明，流感感染后3天，小鼠对耐甲氧西林金黄色葡萄球菌（MRSA）超级感染的易感性降低，但这段时间内的超级感染加剧了流感疾病。这是由于IL-13信号有利于通过抑制IFN-γ解决MRSA感染，但不利于清除流感病毒。然而，如果超级感染直到流感感染接近消退（第7天）才发生，IL-13信号被抑制，至少部分是由于IL-13诱饵受体（IL-13Rα2）的上调，这反过来导致IFN-γ信号的增加和细菌感染的加剧。了解这些细胞因子后遗症对于开发流感-MRSA合并感染的免疫疗法至关重要，因为在错误的时间干扰这些后遗症可能会增加对MRSA和/或流感的易感性。
Super infection in mice at day 7 post-influenza infection exacerbates bacterial pneumonia at least in part via downstream effects of increased IFN-γ signaling. Here we show that up to 3 days post-influenza infection mice have reduced susceptibility to super infection with methicillin-resistant Staphylococcus aureus (MRSA), but that super infection during that time exacerbated influenza disease. This was due to IL-13 signaling that was advantageous for resolving MRSA infection via inhibition of IFN-γ, but was detrimental to clearance of influenza virus. However, if super infection did not occur until the near resolution of influenza infection (day 7), IL-13 signaling was inhibited, at least in part by up regulation of IL-13 decoy receptor (IL-13Rα2), which in turn caused increases in IFN-γ signaling and exacerbation of bacterial infection. Understanding these cytokine sequelae is critical to development of immunotherapies for influenza-MRSA coinfection since perturbations of these sequelae at the wrong time could increase susceptibility to MRSA and/or influenza.
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DOI：
10.1016/s1473-3099(06)70466-2
发表时间：
2006-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Brundage JF
通讯作者：
Brundage JF
DOI：
10.1086/650204
发表时间：
2010-02-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Lee MH;Arrecubieta C;Martin FJ;Prince A;Borczuk AC;Lowy FD
通讯作者：
Lowy FD
影响因子：
4.4
作者：
Wiley, JA;Tighe, MP;Harmsen, AG
通讯作者：
Harmsen, AG
影响因子：
6.4
作者：
Iverson, Amy R.;Boyd, Kelli L.;McCullers, Jonathan A.
通讯作者：
McCullers, Jonathan A.
影响因子：
14.2
作者：
Campbell-Harding, Gemma;Sawkins, Hannah;Andrews, Allison-Lynn
通讯作者：
Andrews, Allison-Lynn