The new kids on the block: Emerging obesogens.
The new kids on the block: Emerging obesogens.
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DOI：
10.1016/bs.apha.2021.05.003
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Veiga-Lopez A
中科院分区：
文献类型：
--
作者：
Chamorro-Garcia R;Veiga-Lopez A
目前的肥胖流行病要求采取行动，确定促成因素。虽然社会和生活方式因素传统上与代谢紊乱有关，但内分泌干扰化学品（EDCs）的一个子集（称为肥胖素）因其促进脂肪组织分化和积累的能力而受到越来越多的关注。对于某些化学品，如三丁基锡，有确凿的证据表明它们能够促进脂肪生成及其作用机制。近年来，具有致肥胖潜力的化学物质的清单正在增加。在这一章中，我们回顾了目前的知识，在该领域的最新发展，新兴的肥胖与食品添加剂，表面活性剂，防晒霜的具体重点，其中许多行动的机制仍然不清楚。我们还审查了新的证据，相对于环境相关的化学混合物的致肥胖的潜力，并指出潜在的治疗方法，以尽量减少肥胖的有害影响。最后，我们讨论了现有的工具来研究新的致肥胖化学物质，策略，以最大限度地提高脂肪形成研究的可重复性，以及未来的方向，这将有助于推动该领域的发展。
The current obesity epidemic is calling for action in the determination of contributing factors. Although social and life-style factors have been traditionally associated with metabolic disruption, a subset of endocrine-disrupting chemicals (EDCs), called obesogens are garnering increasing attention for their ability to promote adipose tissue differentiation and accumulation. For some chemicals, such as tributyltin, there is conclusive evidence regarding their ability to promote adipogenesis and their mechanism of action. In recent years, the list of chemicals that exert obesogenic potential is increasing. In this chapter, we review current knowledge of the most recent developments in the field of emerging obesogens with a specific focus on food additives, surfactants, sunscreens for many of which the mechanism of action remains unclear. We also review new evidence relative to the obesogenic potential of environmentally relevant chemical mixtures and point to potential therapeutic approaches to minimize the detrimental effects of obesogens. We conclude by discussing the available tools to investigate new obesogenic chemicals, strategies to maximize reproducibility in adipogenic studies, and future directions that will help propel the field forward.
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影响因子：
13.6
作者：
Geyer R;Jambeck JR;Law KL
通讯作者：
Law KL
DOI：
10.1038/nrendo.2017.42
发表时间：
2017-08
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Foulds CE;Treviño LS;York B;Walker CL
通讯作者：
Walker CL
影响因子：
10.4
作者：
Chamorro-García R;Shoucri BM;Willner S;Käch H;Janesick A;Blumberg B
通讯作者：
Blumberg B
影响因子：
3.7
作者：
Ariemma F;D'Esposito V;Liguoro D;Oriente F;Cabaro S;Liotti A;Cimmino I;Longo M;Beguinot F;Formisano P;Valentino R
通讯作者：
Valentino R
影响因子：
5.2
作者：
Balise, Victoria D.;Cornelius-Green, Jennifer N.;Nagel, Susan C.
通讯作者：
Nagel, Susan C.