Endocrine-disrupting chemicals and fatty liver disease.
Endocrine-disrupting chemicals and fatty liver disease.
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DOI：
10.1038/nrendo.2017.42
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Walker CL
中科院分区：
文献类型：
--
作者：
Foulds CE;Treviño LS;York B;Walker CL
非酒精性脂肪性肝病（NAFLD）是一种日益严重的流行病，与西方饮食消费国家中肥胖和糖尿病的增加并行。由于NAFLD可导致危及生命的疾病，如肝硬化和肝细胞癌（HCC），因此需要了解触发其发展和病理进展的因素。虽然根据定义，这种疾病与饮酒无关，但暴露于与其他疾病相关的环境因子可能在NAFLD的发展中发挥作用。在这里，我们专注于一类这些药物，内分泌干扰物（EDCs），以及它们影响与脂肪肝相关的一系列病理条件的启动和进展的潜力。实验研究揭示了EDC暴露可能导致疾病发病的几种潜在机制，包括核激素受体（NR）功能的调节和表观基因组的改变。然而，关于急性和慢性EDC暴露与人类NAFLD发展之间的因果关系，仍有许多问题有待解决。解决这些问题的未来研究不仅有望了解EDC暴露与肝脏疾病之间的联系，而且还有望阐明NAFLD的分子机制以及开发新的预防和治疗机会。
Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic paralleling the increase in obesity and diabetes mellitus seen in Western diet-consuming countries. As NAFLD can lead to life-threatening conditions such as cirrhosis and hepatocellular carcinoma (HCC), an understanding of factors that trigger its development and pathological progression is needed. Although by definition this disease is not associated with alcohol consumption, exposure to environmental agents that have been linked to other diseases might have a role in the development of NAFLD. Here, we focus on one class of these agents, endocrine-disrupting chemicals (EDCs), and their potential to influence the initiation and progression of a cascade of pathological conditions associated with fatty liver. Experimental studies have revealed several potential mechanisms by which EDC exposures might contribute to disease pathogenesis, including modulation of nuclear hormone receptor (NR) function and alteration of the epigenome. However, many questions remain to be addressed about the causal link between acute and chronic EDC exposure and the development of NAFLD in humans. Future studies that address these questions hold promise not only for understanding the linkage between EDC exposure and liver disease, but for elucidating the molecular mechanisms underpinning NAFLD and the development of new prevention and treatment opportunities.
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影响因子：
1.5
作者：
Al-Eryani L;Wahlang B;Falkner KC;Guardiola JJ;Clair HB;Prough RA;Cave M
通讯作者：
Cave M
DOI：
10.1016/j.bbagrm.2016.02.013
发表时间：
2016-09
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Chai SC;Cherian MT;Wang YM;Chen T
通讯作者：
Chen T
DOI：
10.1073/pnas.95.21.12208
发表时间：
1998-10-13
影响因子：
11.1
作者：
Bertilsson, G;Heidrich, J;Berkenstam, A
通讯作者：
Berkenstam, A
影响因子：
10.4
作者：
Calafat AM;Kuklenyik Z;Reidy JA;Caudill SP;Ekong J;Needham LL
通讯作者：
Needham LL
影响因子：
64.5
作者：
Bookout, Angie L.;Jeong, Yangsik;Mangelsdorf, David J.
通讯作者：
Mangelsdorf, David J.