Viral factors associated with cytokine expression during HCV/HIV co-infection.
Viral factors associated with cytokine expression during HCV/HIV co-infection.
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HCV/HIV 共感染期间与细胞因子表达相关的病毒因子。
DOI：
10.1089/jir.2006.0147
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
AidsClinicalTrialsGroupA5071StudyTeam
中科院分区：
文献类型：
--
作者：
Blackard,JasonT;Kang,Minhee;StClair,JBenjamin;Lin,Wenyu;Kamegaya,Yoshitaka;Sherman,KennethE;Koziel,MargaretJames;Peters,MarionG;Andersen,Janet;Chung,RaymondT;AidsClinicalTrialsGroupA5071StudyTeam
Co-infection with human immunodeficiency virus (HIV) is associated with reduced hepatitis C virus (HCV) treatment response and accelerated HCV disease. Cytokines, as mediators of immune responses, inflammation, and fibrogenesis, may underlie important differences in HCV pathogenesis during HIV co-infection. We previously found that serum interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α) increased after HCV therapy with interferon (IFN) in HCV/HIV co-infected patients; however, cytokine levels were not predictive of HCV therapeutic response. Here, we examined viral factors associated with expression of IL-8, TNF-α, and transforming growth factor-β1 (TGF-β1) in uninfected, HCV mono-infected, HIV mono-infected, and HCV/HIV co-infected persons. HIV co-infection was associated with decreased IL-8 detection but not TNF-αdetection. A significant interaction effect demonstrated that HIV infection was associated with elevated TGF-β1 in HCV-positive individuals but not in HCV-negative individuals. The induction of a sustained profibrotic signal, such as TGF-β1, by HIV may cause accelerated liver fibrosis during HCV/HIV co-infection and may hinder the host's ability to mount an effective HCV-specific immune response. Further studies are warranted to identify noninvasive markers of liver disease for the clinical management of HCV disease, particularly when liver biopsies have not been performed or are contraindicated.
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影响因子：
11.8
作者：
Sherman, KE;Rouster, SD;Rajicic, N
通讯作者：
Rajicic, N
血浆转化生长因子β(1) 和血小板活化：对移植受者研究的影响。
影响因子：
--
作者：
B. Coupes;Shelley Williams;I.A.N.S.D. Roberts;Colin D. Short;Paul E. Brenchley
通讯作者：
Paul E. Brenchley
促炎细胞因子 mRNA 的肝内表达和干扰素对慢性丙型肝炎的疗效。
DOI：
--
发表时间：
2008
期刊：
Liver
影响因子：
--
作者：
R. Fukuda;N. Ishimura;S. Ishihara;Aktaruzzaman Chowdhury;N. Moriyama;C. Nogami;T. Miyake;M. Niigaki;Alejandro Tokuda;S. Satoh;Shino Sakai;S. Akagi;M. Watanabe;S. Fukumoto
通讯作者：
S. Fukumoto
影响因子：
3.8
作者：
Chung, RT;Evans, SR;Sherman, KE
通讯作者：
Sherman, KE
慢性丙型肝炎病毒感染中肿瘤坏死因子-α系统的激活。
影响因子：
3.1
作者：
D. Nelson;H. Lim;C. G. Marousis;J. Fang;G. Davis;L. Shen;M. Urdea;J. Kolberg;J. Lau
通讯作者：
J. Lau