Endocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations.
Endocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations.
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DOI：
10.3390/ijms18071425
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发表时间：
2017-07-03
影响因子：
5.6
通讯作者：
Siniscalco D
中科院分区：
文献类型：
--
作者：
Brigida AL;Schultz S;Cascone M;Antonucci N;Siniscalco D
一些研究强调了内源性大麻素（EC）系统在自闭症病理生理中的重要作用。EC系统是一个复杂的脂质信号通路网络，由花生四烯酸衍生的化合物（anandamide， AEA）和2-花生四烯醇甘油（2-AG）、它们的g蛋白偶联受体（大麻素受体CB1和CB2）和相关酶组成。除自闭症外，EC系统还涉及其他几种精神疾病（即焦虑、重度抑郁症、双相情感障碍和精神分裂症）。该系统是自闭症中涉及的代谢和细胞途径的关键调节器，如食物摄入、能量代谢和免疫系统控制。早期对自闭症动物模型的研究表明，大脑的EC系统发生了变化。自闭症的另一个特征是免疫系统失调。这种改变包括单核细胞和巨噬细胞反应的差异，以及细胞因子和T细胞水平的异常。自闭症单核细胞和巨噬细胞模型中的EC系统功能障碍已被证实，CB2受体和EC酶的mRNA和蛋白质显着失调，进一步表明EC系统参与自闭症相关的免疫破坏。综上所述，这些新发现为自闭症研究提供了一个新的视角，并表明EC系统可能代表自闭症药物治疗的一个新的目标选择。
Several studies highlight a key involvement of endocannabinoid (EC) system in autism pathophysiology. The EC system is a complex network of lipid signaling pathways comprised of arachidonic acid-derived compounds (anandamide, AEA) and 2-arachidonoyl glycerol (2-AG), their G-protein-coupled receptors (cannabinoid receptors CB1 and CB2) and the associated enzymes. In addition to autism, the EC system is also involved in several other psychiatric disorders (i.e., anxiety, major depression, bipolar disorder and schizophrenia). This system is a key regulator of metabolic and cellular pathways involved in autism, such as food intake, energy metabolism and immune system control. Early studies in autism animal models have demonstrated alterations in the brain’s EC system. Autism is also characterized by immune system dysregulation. This alteration includes differential monocyte and macrophage responses, and abnormal cytokine and T cell levels. EC system dysfunction in a monocyte and macrophagic cellular model of autism has been demonstrated by showing that the mRNA and protein for CB2 receptor and EC enzymes were significantly dysregulated, further indicating the involvement of the EC system in autism-associated immunological disruptions. Taken together, these new findings offer a novel perspective in autism research and indicate that the EC system could represent a novel target option for autism pharmacotherapy.
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影响因子：
3
作者：
Carrier, E. J.;Patel, S.;Hillard, C. J.
通讯作者：
Hillard, C. J.
影响因子：
5.1
作者：
Connolly, AM;Chez, MG;Deuel, RK
通讯作者：
Deuel, RK
DOI：
10.1097/mpg.0b013e3181dcc4a5
发表时间：
2010-10-01
影响因子：
2.9
作者：
de Magistris, Laura;Familiari, Valeria;Bravaccio, Carmela
通讯作者：
Bravaccio, Carmela
影响因子：
4.4
作者：
Aube, Benoit;Levesque, Sebastien A.;Lacroix, Steve
通讯作者：
Lacroix, Steve
影响因子：
7.3
作者：
Borrelli, Francesca;Romano, Barbara;Izzo, Angelo A.
通讯作者：
Izzo, Angelo A.