Causal effects of psychosocial factors on chronic back pain: a bidirectional Mendelian randomisation study.
Causal effects of psychosocial factors on chronic back pain: a bidirectional Mendelian randomisation study.
复制标题
心理社会因素对慢性背痛的因果影响：一项双向孟德尔随机化研究
DOI：
10.1007/s00586-022-07263-2
复制
发表时间：
2022-07
影响因子：
2.8
通讯作者：
Suri, Pradeep
中科院分区：
文献类型：
--
作者：
Williams, Frances M. K.;Elgaeva, Elizaveta E.;Freidin, Maxim B.;Zaytseva, Olga O.;Aulchenko, Yurii S.;Tsepilov, Yakov A.;Suri, Pradeep
慢性背痛（CBP）的风险因素可能具有共同的潜在遗传因素，这使得它们难以用传统方法进行研究。我们进行了一项双向孟德尔随机化（MR）研究，以检查危险因素（教育、吸烟、饮酒、体育活动、睡眠和抑郁）对CBP的因果影响，以及CBP对相同危险因素的因果影响。风险因素和CBP的遗传工具来自已发表的欧洲血统个体风险因素特征全基因组关联研究（GWAS）。我们使用逆加权方差荟萃分析（IVW）、使用总结效应的因果分析（CAUSE）和敏感性分析来检验因果关联的证据。如果IVW或CAUSE的结果在考虑多个统计检验后具有统计学意义（p<0.003），并且IVW、CAUSE和敏感性分析之间的效应估计方向和大小一致，我们将暴露-结果关联解释为与因果关系一致。我们发现证据表明，高等教育（每4.2年受教育的OR= 0.54）、曾经吸烟（OR=1.27）、更多饮酒（每消费类别增加的OR=1.29）和重度抑郁症（OR=1.41）与CBP风险之间存在统计学上显著的因果关系。相反，我们发现了CBP与大量饮酒（OR=1.19）以及CBP与吸烟（OR=1.21）之间存在显著因果关系的证据。其他关系不符合我们预先定义的因果关系标准。受教育年限较短、吸烟、酗酒和重度抑郁症会增加CBP的风险。CBP增加了酗酒和吸烟的风险。
Risk factors for chronic back pain (CBP) may share underlying genetic factors, making them difficult to study using conventional methods. We conducted a bi-directional Mendelian randomisation (MR) study to examine the causal effects of risk factors (education, smoking, alcohol consumption, physical activity, sleep and depression) on CBP and the causal effect of CBP on the same risk factors. Genetic instruments for risk factors and CBP were obtained from the largest published genome-wide association studies (GWAS) of risk factor traits conducted in individuals of European ancestry. We used inverse weighted variance meta-analysis (IVW), Causal Analysis Using Summary Effect (CAUSE) and sensitivity analyses to examine evidence for causal associations. We interpreted exposure-outcome associations as being consistent with a causal relationship if results with IVW or CAUSE were statistically significant after accounting for multiple statistical testing (p<0.003), and the direction and magnitude of effect estimates were concordant between IVW, CAUSE, and sensitivity analyses. We found evidence for statistically significant causal associations between greater education (OR per 4.2 years of schooling=0.54), ever smoking (OR=1.27), greater alcohol consumption (OR=1.29 per consumption category increase) and major depressive disorder (OR=1.41) and risk of CBP. Conversely, we found evidence for significant causal associations between CBP and greater alcohol consumption (OR=1.19) and between CBP and smoking (OR=1.21). Other relationships did not meet our pre-defined criteria for causal association. Fewer years of schooling, smoking, greater alcohol consumption, and major depressive disorder increase the risk of CBP. CBP increases the risk of greater alcohol consumption and smoking.
登录
查看更多内容
影响因子：
2.3
作者：
Hestbaek L;Leboeuf-Yde C;Kyvik KO
通讯作者：
Kyvik KO
基因发现和多基因预测，从基因组全基因组协会的教育程度研究中，有110万个人。
影响因子：
30.8
作者：
Lee JJ;Wedow R;Okbay A;Kong E;Maghzian O;Zacher M;Nguyen-Viet TA;Bowers P;Sidorenko J;Karlsson Linnér R;Fontana MA;Kundu T;Lee C;Li H;Li R;Royer R;Timshel PN;Walters RK;Willoughby EA;Yengo L;23andMe Research Team;COGENT (Cognitive Genomics Consortium);Social Science Genetic Association Consortium;Alver M;Bao Y;Clark DW;Day FR;Furlotte NA;Joshi PK;Kemper KE;Kleinman A;Langenberg C;Mägi R;Trampush JW;Verma SS;Wu Y;Lam M;Zhao JH;Zheng Z;Boardman JD;Campbell H;Freese J;Harris KM;Hayward C;Herd P;Kumari M;Lencz T;Luan J;Malhotra AK;Metspalu A;Milani L;Ong KK;Perry JRB;Porteous DJ;Ritchie MD;Smart MC;Smith BH;Tung JY;Wareham NJ;Wilson JF;Beauchamp JP;Conley DC;Esko T;Lehrer SF;Magnusson PKE;Oskarsson S;Pers TH;Robinson MR;Thom K;Watson C;Chabris CF;Meyer MN;Laibson DI;Yang J;Johannesson M;Koellinger PD;Turley P;Visscher PM;Benjamin DJ;Cesarini D
通讯作者：
Cesarini D
DOI：
10.1016/j.berh.2010.10.002
发表时间：
2010-12-01
影响因子：
5.2
作者：
Hoy, D.;Brooks, P.;Buchbinder, R.
通讯作者：
Buchbinder, R.
影响因子：
0.9
作者：
Shashkova TI;Gorev DD;Pakhomov ED;Shadrina AS;Sharapov SZ;Tsepilov YA;Karssen LC;Aulchenko YS
通讯作者：
Aulchenko YS
DOI：
10.1136/bmj.k601
发表时间：
2018-07-12
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Davies NM;Holmes MV;Davey Smith G
通讯作者：
Davey Smith G