Mechanisms of Antibiotic Resistance in Important Gram-Positive and Gram-Negative Pathogens and Novel Antibiotic Solutions.
Mechanisms of Antibiotic Resistance in Important Gram-Positive and Gram-Negative Pathogens and Novel Antibiotic Solutions.
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重要的革兰氏阳性和革兰氏阴性病原体和新型抗生素溶液中抗生素抗性的机制。
DOI：
10.3390/antibiotics10040415
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发表时间：
2021-04-10
期刊：
影响因子：
--
通讯作者：
Panos G
中科院分区：
文献类型：
--
作者：
Kakoullis L;Papachristodoulou E;Chra P;Panos G
多重耐药细菌对人类健康产生了巨大的影响，因为它们每年仅在欧盟就造成670，000多例感染和33，000例死亡。其中，绝大多数感染和死亡是由少数几个物种引起的--多重耐药大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌、肠球菌属，不动杆菌属和肺炎克雷伯氏菌。这些病原体采用多种抗生素抗性机制，例如抗生素失活酶的产生、抗生素靶标的改变或细胞内抗生素浓度的降低，这使得它们对多种抗生素不敏感。本文旨在以临床方式总结这6种病原体的耐药机制，以及最近开发的旨在克服它们的抗生素的机制。通过对抗生素耐药机制的基本了解，临床医生可以更好地理解和预测耐药模式，即使是对抗生素的耐药谱没有报告，并可以随后选择最合适的抗生素的病原体的问题。
Multidrug-resistant bacteria have on overwhelming impact on human health, as they cause over 670,000 infections and 33,000 deaths annually in the European Union alone. Of these, the vast majority of infections and deaths are caused by only a handful of species—multi-drug resistant Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp. and Klebsiella pneumoniae. These pathogens employ a multitude of antibiotic resistance mechanisms, such as the production of antibiotic deactivating enzymes, changes in antibiotic targets, or a reduction of intracellular antibiotic concentration, which render them insusceptible to multiple antibiotics. The purpose of this review is to summarize in a clinical manner the resistance mechanisms of each of these 6 pathogens, as well as the mechanisms of recently developed antibiotics designed to overcome them. Through a basic understanding of the mechanisms of antibiotic resistance, the clinician can better comprehend and predict resistance patterns even to antibiotics not reported on the antibiogram and can subsequently select the most appropriate antibiotic for the pathogen in question.
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DOI：
10.1053/srin.2002.34693
发表时间：
2002-09-01
期刊：
Seminars in respiratory infections
影响因子：
--
作者：
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通讯作者：
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DOI：
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发表时间：
2017-08-01
影响因子：
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作者：
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Hirsch, Elizabeth B.
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作者：
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