Cerebrospinal fluid pharmacology: an improved pharmacology approach for chinese herbal medicine research.
Cerebrospinal fluid pharmacology: an improved pharmacology approach for chinese herbal medicine research.
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DOI：
10.1155/2013/674305
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kang LY
中科院分区：
文献类型：
--
作者：
Wu YQ;Zhou YW;Qin XD;Hua SY;Zhang YL;Kang LY
尽管中草药在神经系统疾病的治疗和预防中取得了许多成功的应用，但由于缺乏合适的方法来探讨中草药的组合规律、协同作用机制和分子基础，阻碍了对中草药作用机制的全面科学认识。脑脊液药理学是一种改进的药理学方法，它基于脑脊液在维持神经元和神经胶质细胞特定生存环境中的重要作用，已被建立并应用于中药治疗ND的研究。本文简要介绍了CSFP的概念和优点。 对CSFP在CHM研究中的方法和关键技术进行了整理和分析。在此基础上，总结了CSFP的发展趋势，并提出了CSFP在CHM研究中的框架。总之，CSFP不仅为消除中药治疗ND研究的一些障碍提供了新的策略，而且为拓宽中药与现代医学之间的差距的药理学研究提供了新的思路。同时，CSFP的研究进展也将为中药有效成分的发现带来新的概念性进展，为中药现代化和全球化做出重要贡献。
Despite many successful applications of Chinese herbal medicine (CHM) in the treatment and prevention of neurological diseases (ND), the fully scientific understanding of CHM's action mechanisms had been hampered for lack of appropriate methods to explore the combinatorial rules, the synergistic mechanisms, and the molecular basis of CHM. As an improved pharmacology approach, cerebrospinal fluid pharmacology (CSFP), based on the fact that cerebrospinal fluid plays an important role in the health maintenance of specific survival environment for neurons and glial cells, has been constructed and applied to CHM research for treating ND. In the present review, the concept and advantages of CSFP are briefly introduced. The approaches and key technologies of CSFP in CHM research are also collated and analyzed. Furthermore, the developing tendency of CSFP is summarized, and its framework in CHM research is also proposed. In summary, CSFP provides a new strategy not only to eliminate some barriers of CHM research for treating ND, but also to broaden the pharmacology research for bridging the gap between CHM and modern medicine. Moreover, the advancements in CSFP will bring about a conceptual move in active ingredients discovery of CHM and make a significant contribution to CHM modernization and globalization.
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影响因子：
3.7
作者：
Chen, Kuan-Yu;Chang, Su-Sen;Chen, Calvin Yu-Chian
通讯作者：
Chen, Calvin Yu-Chian
影响因子：
7.6
作者：
Li T;Peng T
通讯作者：
Peng T
影响因子：
3.7
作者：
Chen CY
通讯作者：
Chen CY
影响因子：
7.7
作者：
Li, Wei-Feng;Jiang, Jian-Guo;Chen, Jian
通讯作者：
Chen, Jian
影响因子：
--
作者：
Chang, Tung-Ti;Chen, Kuan-Chung;Chen, Calvin Yu-Chian
通讯作者：
Chen, Calvin Yu-Chian