Traditional Chinese herbal medicine as a source of molecules with antiviral activity.
Traditional Chinese herbal medicine as a source of molecules with antiviral activity.
复制标题
DOI：
10.1016/j.antiviral.2012.10.006
复制
发表时间：
2013-01
影响因子：
7.6
通讯作者：
Peng T
中科院分区：
文献类型：
--
作者：
Li T;Peng T
在中国，许多传统的中草药被用来治疗病毒感染。这些中药可能含有具有抗病毒活性的类药物分子。►通过活性引导分离，可能在中药中发现新的抗病毒化合物。大型数据库的发展有助于对中药中活性分子的研究。中药被广泛应用于病毒性传染病的预防和治疗。然而，中药的作用机制在很大程度上仍然是模糊的，主要是因为其复杂性和研究的碎片性。近年来，人们发展了系统的方法来发现中药中的活性化合物并阐明其潜在机制。本文综述了近年来中国和其他亚洲国家基于中药的抗病毒研究进展。特别地，本文综述了针对病毒复制周期的关键步骤和宿主防御系统的关键细胞成分的进展。本文还总结了集中和标准化中药筛选和数据库的最新进展。
► Many traditional Chinese herbal medicines (TCHM) are used in China for the treatment of viral infections. ► These TCHM may contain drug-like molecules with antiviral activity. ► Novel antiviral compounds may potentially be identified in TCHM through activity-guided fractionation. ► Research on active molecules in TCHM is being aided by the development of large databases. Traditional Chinese herbal medicine (TCHM) is widely used in the prevention and treatment of viral infectious diseases. However, the operative mechanisms of TCHM remain largely obscure, mainly because of its complicated nature and the fragmented nature of research. In recent years, systematic methodologies have been developed to discover the active compounds in TCHM and to elucidate its underlying mechanisms. In this review, we summarize recent progress in TCHM-based antiviral research in China and other Asian countries. In particular, this review focuses on progress in targeting key steps in the viral replication cycle and key cellular components of the host defense system. Recent developments in centralized and standardized TCHM screening and databases are also summarized.
登录
查看更多内容
影响因子：
7.6
作者：
Ho TY;Wu SL;Chen JC;Li CC;Hsiang CY
通讯作者：
Hsiang CY
影响因子：
7.6
作者：
Chen X;Wang Z;Yang Z;Wang J;Xu Y;Tan RX;Li E
通讯作者：
Li E
影响因子：
2.7
作者：
Ding, PL;Liao, ZX;Chen, DF
通讯作者：
Chen, DF
影响因子：
3.7
作者：
Chen CY
通讯作者：
Chen CY
影响因子：
5.2
作者：
Cheng, HY;Lin, TC;Lin, CC
通讯作者：
Lin, CC