Potential regulatory functions of microRNAs in the ovary.
Potential regulatory functions of microRNAs in the ovary.
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DOI：
10.1055/s-0028-1096127
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发表时间：
2008-11
影响因子：
2.7
通讯作者：
Chegini N
中科院分区：
文献类型：
--
作者：
Toloubeydokhti T;Bukulmez O;Chegini N
卵巢生殖细胞和体细胞之间的相互作用以及卵巢内多种自分泌/旁分泌调节因子的表达是卵巢发育的主要因素。这些卵巢内介质调节各种卵巢细胞活动，包括细胞生长、分化和凋亡，这些在卵泡发育中是至关重要的。Micro-RNAs(MiRNAs)已成为转录后基因表达的重要组成部分。最近在小鼠身上产生的证据表明，miRNAs在卵母细胞成熟和卵巢卵泡发育中具有调节功能。在人类中，miRNAs可能针对颗粒细胞中的特定基因表达，参与卵巢癌的发生和发展。在此，我们综述了目前有关miRNAs在正常和病理条件下在卵巢中的表达和潜在调节功能的信息。了解卵巢生殖细胞和体细胞miRNAs调控的潜在机制，并确定其特定的靶基因及其功能，可能有助于开发实现靶基因调控的策略，以预防和治疗各种卵巢疾病。
The interactions between ovarian germ and somatic cells and expression of several intraovarian autocrine/paracrine regulators are major contributing factors in the ovary. These intraovarian mediators regulate various ovarian cellular activities including cell growth, differentiation, and apoptosis, which are critical in follicular development. Micro-RNAs (miRNAs) have emerged as key components of posttranscriptional gene expression. Recent evidence generated in mice implicates the regulatory function of miRNAs in oocyte maturation and ovarian follicular development. In the human, miRNAs may target specific gene expression in granulosa cells and participate in establishment and progression of ovarian cancer. Here, we review the currently available information on the expression and potential regulatory functions of miRNAs in the ovary under normal and pathologic conditions. Understanding the underlying mechanisms of how ovarian germ cell and somatic cell miRNAs are regulated and identifying their specific target genes and their functions may lead to the development of strategies to achieve target-specific gene regulation for the prevention and treatment of various ovarian disorders.
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Amsterdam, A
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