Alternative splicing and cancer: a systematic review.
Alternative splicing and cancer: a systematic review.
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DOI：
10.1038/s41392-021-00486-7
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发表时间：
2021-02-24
影响因子：
39.3
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Zhang Y;Qian J;Gu C;Yang Y
选择性剪接调控的异常往往伴随着肿瘤的发生发展，产生多种不同的异构体，使蛋白质表达多样化。本研究的目的是对选择性剪接的调控机制及其在肿瘤细胞从增殖和凋亡到侵袭和转移以及从血管生成到代谢的功能进行系统的综述。异常剪接事件作为致癌驱动因素和/或旁观者因素促进了肿瘤的进展。在肿瘤中检测到的剪接因子的变化以及肿瘤发生中的其他错误剪接事件(即长非编码和环状RNA)也被包括在内。介绍了以剪接催化和剪接调控蛋白为靶点来调节病理性剪接事件(包括肿瘤特异性新抗原用于癌症免疫治疗)的最新治疗方法的研究结果。还讨论了新出现的基于RNA的治疗具有异常选择性剪接异构体的癌症的策略。然而，仍需要进一步的研究来更详细地解决选择性剪接与癌症之间的联系。
The abnormal regulation of alternative splicing is usually accompanied by the occurrence and development of tumors, which would produce multiple different isoforms and diversify protein expression. The aim of the present study was to conduct a systematic review in order to describe the regulatory mechanisms of alternative splicing, as well as its functions in tumor cells, from proliferation and apoptosis to invasion and metastasis, and from angiogenesis to metabolism. The abnormal splicing events contributed to tumor progression as oncogenic drivers and/or bystander factors. The alterations in splicing factors detected in tumors and other mis-splicing events (i.e., long non-coding and circular RNAs) in tumorigenesis were also included. The findings of recent therapeutic approaches targeting splicing catalysis and splicing regulatory proteins to modulate pathogenically spliced events (including tumor-specific neo-antigens for cancer immunotherapy) were introduced. The emerging RNA-based strategies for the treatment of cancer with abnormally alternative splicing isoforms were also discussed. However, further studies are still required to address the association between alternative splicing and cancer in more detail.
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影响因子：
29
作者：
Babic I;Anderson ES;Tanaka K;Guo D;Masui K;Li B;Zhu S;Gu Y;Villa GR;Akhavan D;Nathanson D;Gini B;Mareninov S;Li R;Camacho CE;Kurdistani SK;Eskin A;Nelson SF;Yong WH;Cavenee WK;Cloughesy TF;Christofk HR;Black DL;Mischel PS
通讯作者：
Mischel PS
影响因子：
7.3
作者：
Busch, Anke;Hertel, Klemens J.
通讯作者：
Hertel, Klemens J.
影响因子：
3.7
作者：
Chang JG;Yang DM;Chang WH;Chow LP;Chan WL;Lin HH;Huang HD;Chang YS;Hung CH;Yang WK
通讯作者：
Yang WK
影响因子：
64.8
作者：
Abudayyeh OO;Gootenberg JS;Essletzbichler P;Han S;Joung J;Belanto JJ;Verdine V;Cox DBT;Kellner MJ;Regev A;Lander ES;Voytas DF;Ting AY;Zhang F
通讯作者：
Zhang F
影响因子：
--
作者：
Alieva AKh;Shadrina MI;Filatova EV;Karabanov AV;Illarioshkin SN;Limborska SA;Slominsky PA
通讯作者：
Slominsky PA