Methods and Measures for Investigating Microscale Motility.

Methods and Measures for Investigating Microscale Motility.
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DOI:
10.1093/icb/icad075
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发表时间:
2023-12-29
影响因子:
2.6
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
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运动性是生物体生存和多样化的重要因素。随着新型单细胞技术、分析框架和理论方法的出现,我们可以开始探索微观运动生物体的复杂生命,并回答这些不同的生命形式如何在周围环境中导航的相互交织的生物学和物理问题。在此,我们总结了微尺度运动的主要机制,并概述了用于在分子、个体和群体水平等不同尺度上研究它们的不同实验、分析和数学方法。我们确定该领域的可转移技术、紧迫挑战和未来方向。对于有兴趣探索和量化微观世界中生物体运动的研究人员来说,这篇综述可以作为一个起点。
Motility is an essential factor for an organism’s survival and diversification. With the advent of novel single-cell technologies, analytical frameworks, and theoretical methods, we can begin to probe the complex lives of microscopic motile organisms and answer the intertwining biological and physical questions of how these diverse lifeforms navigate their surroundings. Herein, we summarize the main mechanisms of microscale motility and give an overview of different experimental, analytical, and mathematical methods used to study them across different scales encompassing the molecular-, individual-, to population-level. We identify transferable techniques, pressing challenges, and future directions in the field. This review can serve as a starting point for researchers who are interested in exploring and quantifying the movements of organisms in the microscale world.
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