Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study.
Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study.
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DOI：
10.1186/s10194-021-01340-5
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发表时间：
2021-10-23
期刊：
影响因子：
--
通讯作者：
Seminowicz DA
中科院分区：
文献类型：
--
作者：
Burrowes SAB;Goloubeva O;Keaser ML;Haythornthwaite JA;Seminowicz DA
偏头痛患者很难得到适当的护理和治疗。偏头痛与几个脑区的灰质体积（GMV）减少有关，这可能与该疾病的各种临床特征有关。研究既往接受过偏头痛临床治疗和未接受过偏头痛临床治疗的偏头痛患者GMV的差异，并研究偏头痛临床变量、心理社会症状及其与GMV的关系的差异。我们使用了一项纵向随机对照试验的基线MRI扫描和心理社会症状问卷。偏头痛的既往治疗由医生诊断或偏头痛特定药物处方确定。117名患者被纳入研究。与接受过既往治疗的患者相比，未接受过既往治疗的患者（n=23）右侧背内侧前额叶皮质（dMPFC）的GMV降低（p=0.034，FWE校正）。与健康对照组（n=36）相比，两个患者组的GMV均降低。患者组在头痛临床变量方面没有差异。无论护理状态如何，压力（感知压力评分）和抑郁问卷（患者健康问卷）评分的增加与dMPFC中GMV的增加相关。临床护理可能会影响偏头痛患者的GMV。患者可能需要不同的治疗方案来解决这种基线缺陷。NCT02133209。在线版本包含补充材料，可通过10.1186/s10194-021-01340-5获得。
Migraine sufferers face difficulties getting appropriate care and treatment. Migraine is associated with reduced gray matter volume (GMV) in several brain regions, which could be related to various clinical characteristics of the disorder. To examine differences in GMV in migraine patients with and without prior clinical care for migraine and examine differences in migraine clinical variables, psychosocial symptoms and their relationship with GMV. We utilized the baseline MRI scan and psychosocial symptom questionnaires from a longitudinal randomized controlled trial. Prior care of migraine was determined by diagnosis by a medical practitioner or prescription of migraine specific medication. 117 patients were included in the study. Patients without prior care (n=23) had reduced GMV in the right dorsal medial prefrontal cortex (dMPFC) relative to patients who had prior care (p=0.034, FWE corrected). Both patient groups had reduced GMV compared to healthy controls (n=36). Patient groups did not differ in headache clinical variables. Regardless of care status, increasing scores on the stress (Perceived Stress Score) and depression questionnaires (Patient Health Questionnaire) were associated with increased GMV in the dMPFC. Clinical care may impact GMV in migraine patients. Patients may need different treatment options to address this baseline deficit. NCT02133209. The online version contains supplementary material available at 10.1186/s10194-021-01340-5.
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影响因子：
5.3
作者：
Seminowicz, David A.;Wideman, Timothy H.;Stone, Laura S.
通讯作者：
Stone, Laura S.
偏头痛慢性化过程中大脑区域体积的变化
影响因子：
6.1
作者：
Chen, Xiao-Yan;Chen, Zhi-Ye;Yu, Sheng-Yuan
通讯作者：
Yu, Sheng-Yuan
影响因子：
5
作者：
Lipton, Richard B.;Serrano, Daniel;Buse, Dawn C.
通讯作者：
Buse, Dawn C.
影响因子：
9.9
作者：
Lipton, RB;Scher, AI;Stewart, WF
通讯作者：
Stewart, WF
DOI：
10.1186/s10194-018-0834-6
发表时间：
2018-01-15
期刊：
The journal of headache and pain
影响因子：
--
作者：
Chen WT;Chou KH;Lee PL;Hsiao FJ;Niddam DM;Lai KL;Fuh JL;Lin CP;Wang SJ
通讯作者：
Wang SJ